Drug Delivery to the Lung

Overview

This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice.

Examines the behavior of inspired spherical particles in the respiratory tract!

Featuring over 1300 references, drawings, tables, photographs, and ...

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Overview

This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice.

Examines the behavior of inspired spherical particles in the respiratory tract!

Featuring over 1300 references, drawings, tables, photographs, and micrographs, Drug Delivery to the Lung

  • outlines the history of inhaled medications in the treatment of respiratory disease
  • describes aspects of respiratory structure to inhalation therapy emphasizing developmental changes
  • compares existing in vitro/in vivo correlations for key aerosol modalities with lung model predictions
  • discusses particle diameter measurement, particle size statistics, and aerosol test methods
  • reviews the clinical effects of altering the deposition site of various classes of aerosolized drugs
  • surveys the development of novel, efficient, and convenient nebulizer systems
  • details breath-actuated and spacer devices constructed for children
  • analyzes dry-powder and pressurized metered dose inhalers
  • considers the transition from CFCs to new environmentally friendly chemical propellants
  • and more!
    Giving the clinician an overview of factors essential to understanding drug delivery via nebulization, Drug Delivery to the Lung is a superlative reference for pulmonologists; physiologists; pharmaceutical scientists; immunologists; allergists; analytical, organic, and medicinal chemists and biochemists; chemical, genetic, and process engineers; and medical and graduate school students in these disciplines.
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Editorial Reviews

Doody's Review Service
Reviewer: Alexander B. Adams, RRT (Regions Hospital)
Description: This book, volume 162 in the invaluable series, Lung Biology in Health and Disease, assembles experts in the complex area of aerosol/drug delivery to the lungs. In contrast to a previous volume on inhalational aerosols, this book emphasizes the care delivery aspects of aerosol therapy.
Purpose: This is a complete, updated review of the care delivery issues of aerosol therapy. Several points made throughout the book meet important objectives: in vitro testing must be viewed skeptically, new devices are becoming available that will improve compliance and delivery efficiency, and aerosol delivery has a promising (and currently unregulated) future.
Audience: The book is intended for clinicians, therapists, and nurses, that is, the care providers. It is scholarly reviews on a number of topics, yet several chapters are pertinent for practitioners — nebulization: the device and clinical considerations, new nebulizer technology, the metered-dose inhaler, spacer devices, and dry-powdered inhalers. The authors are credible authorities.
Features: Generally, the book provides background for the topic in a fascinating chapter on the history of aerosol therapy followed by chapters on particle behavior in the respiratory tract and lung structure/function. Subsequent chapters are on testing of devices (in vitro vs. in vivo) with whole chapters on metered dose and dry powdered inhalers. The last chapter is on the difficult issue of compliance when compliance may be a technique problem. This book's strength is the completeness of the reviews.
Assessment: The book is extremely high quality and it becomes an important reference in the area of aerosol medicine. Other books will devote a single chapter to this topic and none will cover the area to this depth. The chapters on history and compliance are enriching, entertaining, and unique.

3 Stars from Doody
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Product Details

Table of Contents

The History of Inhaled Drug Therapy

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