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Drug Discovery and Design
     

Drug Discovery and Design

by Frederic M. Richards
 

Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics

Overview

Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.

Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This book details the process of drug discovery for several types of reactions. Methods for identification of compounds and their properties are described in detail for each of the examples.
Purpose: The goal of this book is to provide a detailed description of the process of drug development using as examples several well recognized products. This is a useful insight into the field. Given the perspective of the editor, the objectives were met.
Audience: The readers of this book will include advanced graduate students, research personnel, and laboratory managers. The author is a senior official at Merck and highly qualified in the area.
Features: This book details the drug discovery and development process for several classes of pharamcologically important drugs.These include agents that control blood pressure (ACE inhibitors), inhibit protease action, reduce circulating cholesterol, control inflammatory responses, and modulate hormonal receptors. The use of monoclonal antibodies as therapeutic agents is also discussed as is the role of enzyme inhibitors as antifungal agents. In each case, a thorough description of the target as well as the strategy for control/intervention is presented. Overall, the examples represent a cross section of efforts in the industry outside of those agents targeting malignant disease. The bibliographies are thorough and the presentations logically arranged. Not surprisingly, the majority of the authors are connected with Merck (the home of the editor) and whatever bias is present reflects this insularity. Lacking in the book is a clear discussion of the principles of drug design, the role of genomics and proteomics in this process, the value of molecular modeling in the absence of crystallographic data, and procedures for the choice of targets (often driven by market considerations). There is insufficient attention given to high throughput screens or combinatorial methods indicative of the somewhat classic nature of the material presented. These caveats notwithstanding, the book will be of interest to investigators engaged in this type of translational research.
Assessment: The standard of this book is high, but some of the material is dated.
From the Publisher
"This volume will be of interest to medicinal chemists, particularly those involved in drug discovery programs. ...Perhaps among the most interesting lessons to be learned from this text is that we are asking a lot from the drug design and discovery process, and that we are very often able to deliver."
—-Richard A. Hudson, University of Toledo, in JOURNAL OF MEDICINAL CHEMISTRY (2001)
PRAISE FOR THE SERIES
"The authority, originality, and editing of the reviews are first class."
—-NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
—-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
3 Stars from Doody
Richard A. Hudson
This volume will be of interest to medicinal chemists, particularly those involved in drug discovery programs. ...Perhaps among the most interesting lessons to be learned from this text is that we are asking a lot from the drug design and discovery process, and that we are very often able to deliver.

Product Details

ISBN-13:
9780120342563
Publisher:
Elsevier Science
Publication date:
04/09/2001
Series:
Advances in Protein Chemistry Series
Pages:
567
Product dimensions:
6.25(w) x 9.50(h) x (d)

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