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From The CriticsReviewer: Scott J Weir, PharmD, PhD (University of Kansas Medical Center)
Description: This book provides a survey of drug discovery strategies while addressing several important topics and providing practical examples.
Purpose: The objective is to provide greater understanding of the disciplines involved in drug discovery, rather than limiting the scope to medicinal chemistry. I agree with the editor that this approach has been lacking. The book provides a nice survey of most of the key topics facing drug discovery houses today.
Audience: As written, the book is appropriate for graduate students and faculty, as well as pharmaceutical R&D associates who are early in their careers.
Features: This book is not limited to a treatise on medicinal chemistry. Rather, it surveys the drug discovery landscape, addressing medicinal chemistry strategies, screening approaches whether HTS or ADMET, new technologies which will play an important role moving forward, and, finally, practical examples to illustrate concepts and principles. The book does not attempt to be the "War and Peace" of drug discovery. Topics new and old are covered at an appropriate level. When I ask my colleagues in industry what is the most common rate limiting step in drug discovery, the answer routinely comes back "quantitative biology." The constraint is developing and validating bioassays as HTS or secondary screens. I would have liked to see quantitative biology issues, challenges, and current and future directions better covered.
Assessment: The book provides a reasonable overview of drug discovery. Chapters are well written, and the examples are particularly interesting. Coming from the industry, although from different companies than in the examples, I found it interesting to learn how other pharmaceutical companies' agents were discovered and successfully registered.