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This title is directed primarily toward health care professionals outside the United States. An ideal introduction to the pharmaceutical industry, this book describes the process of bringing a new drug to the marketplace. It explains why, although thousands of compounds show initial promise, only a small handful will be developed for human clinical trials and perhaps only one will become an approved drug. Describing the huge complexities involved, it shows how new molecular understanding and techniques can make the process more targeted and successful.
• Includes the new molecular techniques of drug design and development.
• Discusses current therapeutic needs.
• Covers pharmacoepidemiology and pharmacoeconomics.
• Edited by Humphrey Rang, who is also known throughout the world as a co-author of the enormously successful and authoritative textbook, Pharmacology, now in its fifth edition.
• Foreword by Daniel Vasella, CEO, Novartis International.
• Includes contributors from both the pharmaceutical industry and universities.
The book contains black-and-white illustrations.
Section 1: Introduction:
Development of the pharmaceutical industry
Nature of disease and the purpose of therapy
Section 2: Drug discovery
The drug discovery process:
General principles and some case histories
Choosing the project
Choosing the target
The role of genomics and bioinformatics
High throughput screening
The role of chemistry in the drug discovery process
Pharmacokinetic issues in drug discovery
Pharmacology: its role in drug discovery
Patent issues in drug discovery
Organisation of a large drug discovery department
Section 3: Drug development:
Assessing drug safety
Protecting the assets: patenting and intellectual property
Marketing the drug
Section 4: Facts and figures:
Drug discovery and development: Facts and figures