Drug Discovery from Nature / Edition 1

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Overview

This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

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Product Details

  • ISBN-13: 9783540648444
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 12/10/1998
  • Series: Springer Desktop Editions in Chemistry Series
  • Edition description: 1999
  • Edition number: 1
  • Pages: 367
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

The Impact of Natural Products on Drug Discovery.- Recent Developments in Drug DiscoveryTechnologies.- Technical Aspects.- A Central Natural Product Pool- New Approach in Drug Discovery Strategies.- Automation Strategies in Drug Discovery.- Synergistic Use of Combinatorial and Natural Product Chemistry.- Supercritical Fluid Extraction (SFE) - Novel Strategies in the Processing of Biomaterials.- Natural Products from Microbial Sources.- Secondary Metabolites: From Past to Present.- The Chemical Screening Approach.- Myxobaderia as Producers of Secondary Metabolites.- Trends in Marine Biotechnology.- Biochemistry and Molecular Biology Based Methods.- Structure Modification via Biological Derivatization Methods.- Molecular Biological Aspects of Antibiotic Biosynthesis.- Combinatorial Biosynthesis of Antibiotics.- Aspects in Application.- Impact of Natural Products on Cell Biology: Low-Molecular Mass Effectors of Folding Helper Proteins.- Novel Antibacterial Drugs from Microorganisms.- New Antibiotics with Novel Mode of Action.- Synthetic Combinatorial Libraries: A New Tool for Antimicrobial Agent Discovery.- Strobilurins and Oudemansins.

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