Drug Discovery Handbook / Edition 1

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The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.

This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including:

  • Genomics, proteomics, high-throughput screening, and systems biology
  • Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more
  • Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques

The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

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Editorial Reviews

From the Publisher
"...provides in one volume most of the currently used and emerging technologies available...presents a wealth of information on topics that are difficult to find elsewhere...a very useful handbook." (Journal of Medicinal Chemistry, November 2005)

"…will be of great value to medicinal chemists and organic chemists, pharmacologists, physicians, researchers, and everyone interested in the development of therapeutic drugs." (Chemical Educator, September/October 2005)

"...the quality and breadth of the 'Drug Discovery Handbook' make it indispensable for professionals, and endlessly engaging for those interested in discovering more about new drugs..." (Kirkus Reviews, The 2005 Reference Review)

“…an authoritative, comprehensive, and state-of-the-art reference source...thorough coverage and practical, scientifically valid problem-solving approach make it an indispensable aid to anyone involved in the complex task of developing new drugs.” (The Chemical Educator, Vol. 10, No. 5, September/October 2005)

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Product Details

  • ISBN-13: 9780471213840
  • Publisher: Wiley
  • Publication date: 6/28/2005
  • Series: Pharmaceutical Development Series , #10
  • Edition number: 1
  • Pages: 1496
  • Product dimensions: 6.40 (w) x 9.25 (h) x 3.13 (d)

Table of Contents

Introduction : drug discovery in the 21[superscript st] century 1
1 Natural products 11
2 Cancer cell proteomics using molecular aptamers 73
3 Molecular similarity methods and QSAR models as tools for virtual screening 87
4 Systems biology : applications in drug discovery 123
5 High-throughput flow cytometry
6 Combining NMR spectral information with associated structural features to form computationally nonintensive, rugged, and objective models of biological activity 227
7 Using Microsoft Excel as a laboratory data management tool 287
8 Age of regulation 337
9 Simultaneous screening of multiple cell lines using the CellCard system 353
10 Protein X-ray crystallography in drug discovery 373
11 Biological and chemistry assays available during drug discovery and developability assessment 457
12 Strategies and methods in monitoring and targeting protein-protein interactions 483
13 High-throughput screening : evolution of technology and methods 559
14 Metal-enhanced fluorescence : application to high-throughput screening and drug discovery 603
15 Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays 667
16 Coupled luminescent methods in drug discovery : 3-min assays for cytotoxicity and phosphatase activity 689
17 Design and pharmaceutical applications of prodrugs 733
18 GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders 797
19 Cardiac sarcolemmal ATP-sensitive potassium channel antagonists : novel ischemia-selective antiarrhythmic agents 909
20 Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid, and anticoagulant therapies for sepsis 937
21 Combinatorial chemistry in the drug discovery process 961
22 Herbal medicines and animal models of gastrointestinal diseases 1013
23 Endocrine and metabolic agents 1037
24 Respiratory viruses 1105
25 Strategies in the design of antiviral drugs 1135
26 Protein kinase inhibitors in drug discovery 1191
27 RNA-based therapies 1259
28 Novel imaging agents for molecular MR imaging of cancer 1309
29 Targets and approaches for cancer drug discovery 1343
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