Drug Discovery Handbook / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $167.77
Usually ships in 1-2 business days
(Save 27%)
Other sellers (Hardcover)
  • All (8) from $167.77   
  • New (6) from $184.53   
  • Used (2) from $167.77   

Overview

The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.

This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including:

  • Genomics, proteomics, high-throughput screening, and systems biology
  • Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more
  • Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques
The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.
Read More Show Less

Editorial Reviews

From the Publisher
"...provides in one volume most of the currently used and emerging technologies available...presents a wealth of information on topics that are difficult to find elsewhere...a very useful handbook." (Journal of Medicinal Chemistry, November 2005)

"…will be of great value to medicinal chemists and organic chemists, pharmacologists, physicians, researchers, and everyone interested in the development of therapeutic drugs." (Chemical Educator, September/October 2005)

"...the quality and breadth of the 'Drug Discovery Handbook' make it indispensable for professionals, and endlessly engaging for those interested in discovering more about new drugs..." (Kirkus Reviews, The 2005 Reference Review)

“…an authoritative, comprehensive, and state-of-the-art reference source...thorough coverage and practical, scientifically valid problem-solving approach make it an indispensable aid to anyone involved in the complex task of developing new drugs.” (The Chemical Educator, Vol. 10, No. 5, September/October 2005)

Read More Show Less

Product Details

  • ISBN-13: 9780471213840
  • Publisher: Wiley
  • Publication date: 6/28/2005
  • Series: Pharmaceutical Development Series , #10
  • Edition number: 1
  • Pages: 1496
  • Product dimensions: 6.40 (w) x 9.25 (h) x 3.13 (d)

Meet the Author

SHAYNE C. GAD, PHD, DABT, ATS, is the Principal of Gad Consulting Services. He has more than twenty-eight years of experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of twenty-nine books and numerous papers, presentations, and other publications.

Read More Show Less

Table of Contents

Preface.

Introduction: Drug Discovery in the 21st Century.

1. Natural Products (Charles B. Spainhour).

2. Cancer Cell Proteomics Using Molecular Aptamers (Weihong Tan, Zehui Cao, Dihua Shangguan, Ying Li, Zhiwen Tang, Prabodhika Mallikratchy, and Hui Chen).

3. Molecular Similarity Methods and QSAR Models as Tools for Virtual Screening (Jürgen Bajorath).

4. Systems Biology: Applications in Drug Discovery (Sean Ekins, Andrej Bugrim, Yuri Nikolsky, and Tatiana Nikolskaya).

5. High-Throughput Flow Cytometry (Larry A. Sklar, Peter C. Simons, Anna Waller, Sean M. Biggs, Susan M. Young, Marius Olah, Cristian Bologa, Tudor I. Oprea, Eric R. Prossnitz, and Bruce S. Edwards).

6. Combining NMR Spectral Information with Associated Structural Features to Form Computationally Nonintensive, Rugged, and Objective Models of Biological Activity (Richard D. Beger, Dan A. Buzatu, and Jon G.Wilkes).

7. Using Microsoft Excel® as a Laboratory Data Management Tool (A. Erik Rubin, Mark F. Russo, and William Neil).

8. Age of Regulation (Sandy Weinberg and Gerald J. Whartenby).

9. Simultaneous Screening of Multiple Cell Lines Using the CellCard System (Oren E. Beske).

10. Protein X-ray Crystallography in Drug Discovery (Peter Nollert, Michael D. Feese, Bart L. Staker, and Hidong Kim).

11. Biological and Chemistry Assays Available During Drug Discovery and Developability Assessment (Duane B. Lakings).

12. Strategies and Methods in Monitoring and Targeting Protein–Protein Interactions (Arianna Loregian and Giorgio Palù)

13. High-Throughput Screening: Evolution of Technology and Methods (Martyn N. Banks, Angela M. Cacace, Jonathan O’Connell, and John G. Houston).

14. Metal-Enhanced Fluorescence: Application to High-Throughput Screening and Drug Discovery (Kadir Aslan, Ignacy Gryczynski, Joanna Malicka, Joseph R. Lakowicz, and Chris D. Geddes).

15. Methods for the Design and Analysis of Replicate-Experiment Studies to Establish Assay Reproducibility and the Equivalence of Two Potency Assays (Brian J. Eastwood, Amy K. Chesterfield, Mary C.Wolff, and Christian C. Felder).

16. Coupled Luminescent Methods in Drug Discovery: 3-Min Assays for Cytotoxicity and Phosphatase Activity (Michael J. Corey and Robert J. Kinders).

17. Design and Pharmaceutical Applications of Prodrugs (Tomi Järvinen, Jarkko Rautio, Mar Masson, and Thorsteinn Loftsson).

18. GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders (Ulf Madsen, Hans Bräuner-Osborne, Jeremy R. Greenwood, Tommy N. Johansen, Povl Krogsgaard-Larsen, Tommy Liljefors, Mogens Nielsen, and Bente Frølund).

19. Cardiac Sarcolemmal ATP-Sensitive Potassium Channel Antagonists: Novel Ischemia-Selective Antiarrhythmic Agents (George E. Billman).

20. Factors Influencing the Efficacy of Mediator-Specific Anti-Inflammatory, Glucocorticoid, and Anticoagulant Therapies for Sepsis (Peter C. Minneci, Katherine J. Deans, Michael Haley, Xizhong Cui, Charles Natanson, and Peter Q. Eichacker).

21. Combinatorial Chemistry in the Drug Discovery Process (Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller).

22. Herbal Medicines and Animal Models of Gastrointestinal Diseases (C.H. Cho and J.K.S. Ko).

23. Endocrine and Metabolic Agents (Brian L. Furman).

24. Respiratory Viruses (Paul D. Olivo).

25. Strategies in the Design of Antiviral Drugs (Erik De Clercq and Piet Herdewijn).

26. Protein Kinase Inhibitors in Drug Discovery (Keykavous Parang and Gongqin Sun).

27. RNA-Based Therapies (Steve Pascolo).

28. Novel Imaging Agents for Molecular MR Imaging of Cancer (Dmitri Artemov and Zaver M. Bhujwalla).

29. Targets and Approches for Cancer Drug Discovery (Susan L. Mooberry).

Index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)