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Drug Discovery Strategies and Methods

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Overview

Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.

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Product Details

  • ISBN-13: 9780824706913
  • Publisher: Taylor & Francis
  • Publication date: 11/28/2003
  • Pages: 348
  • Product dimensions: 6.00 (w) x 9.00 (h) x 1.00 (d)

Table of Contents

Preface
Contributors
1 Protein Crystallography in Structure-Based Drug Design 1
2 Src Homology-2 Domains and Structure-Based, Small-Molecule Library Approaches to Drug Discovery 23
3 Three-Dimensional Structure of the Inhibited Catalytic Domain of Human Stromelysin-1 by Heteronuclear NMR Spectroscopy 61
4 Cannabinergics: Old and New Possibilities 89
5 Development of PET and SPECT Radioligands for Cannabinoid Receptors 129
6 Structural and Pharmacological Aspects of Peptidomimetics
7 Linkers and Resins for Solid-Phase Synthesis: 1997-1999 175
8 Allosteric Modulation of G-Protein-Coupled Receptors: Implications for Drug Action 221
9 Protein Misfolding and Neurodegenerative Disease: Therapeutic Opportunities 245
10 Uncoating and Adsorption Inhibitors of Rhinovirus Replication 279
11 Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of HIV Infection 309
Index 337
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