Drug-DNA Interactions: Structures and Spectra / Edition 1

Drug-DNA Interactions: Structures and Spectra / Edition 1

by Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan
     
 

ISBN-10: 0471786268

ISBN-13: 9780471786269

Pub. Date: 09/09/2008

Publisher: Wiley

Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current

Overview

Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.

Product Details

ISBN-13:
9780471786269
Publisher:
Wiley
Publication date:
09/09/2008
Series:
Methods of Biochemical Analysis Series, #51
Pages:
378
Product dimensions:
6.30(w) x 9.30(h) x 0.90(d)

Table of Contents

Preface.

Introduction.

1. DNA Structures and Spectra.

1.1. DNA Structures.

1.2. Electronic Spectra.

1.3. Vibrational Spectra.

1.4. NMR Spectra.

1.5. Electron Spin Resonance Spectra.

1.6. X-Ray Crystallography.

1.7. Molecular Modeling an molecular Mechanics.

2. Intercalating Drugs.

2.1. Acridine Dyes.

2.2. Ethidium Bromide.

2.3. Aclacinomycin.

2.4. Sequence Preference.

2.5. Bis- and Tris- Intercalators.

3. Groove- Binding Drugs.

3.1. Netropsin and Distamycin.

3.2. Derivatives of Netropsin and Distamycin.

3.3. Hoechst 33258, SN6999, and their Derivatives.

3.4. Chromomycin, Mithramycin, and Other GC Binders.

3.5. Groove Binding and Intercalation.

4. Covalent Bonding Drugs.

4.1. (+) CC1065 and Related Drugs.

4.2. Anthramycin and Tomaymycin.

4.3. Ecteinascidins.

4.4. Mitomycins.

4.5. Intercalating Alkylators.

5. Strand-Breaking Drugs.

5.1. Bleomycins.

5.2. Enediyne Antibiotics.

6. Metal-Containing Drugs.

6.1. Cisplatin.

6.2. Cisplatin Derivatives.

6.3. Transplatin and Derivatives.

6.4. Monofunctional Platinum Complexes.

6.5. Polynuclear and High-valent Platinum Complexes.

6.6. Complexes Containing Other Metals.

Appendixes.

Index.

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