Drug-Drug Interactions, Second Edition

Overview

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:


  • key interplay between transporters and enzymes in drug metabolism and...
See more details below
Available through our Marketplace sellers.
Other sellers (Hardcover)
  • All (4) from $98.92   
  • New (4) from $98.92   
Close
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any BN.com coupons and promotions
$98.92
Seller since 2011

Feedback rating:

(1)

Condition:

New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

New
New York, NY 2008 Hard cover 2nd ed. New. No dust jacket. Glued binding. Paper over boards. 744 p. Contains: Illustrations. Drugs and the Pharmaceutical Sciences, 179. Audience: ... General/trade. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

Ships from: Oslo, Norway

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
$113.94
Seller since 2014

Feedback rating:

(0)

Condition: New
Hardcover New in new dust jacket. Brand New US edition, 3-5 days shipping!

Ships from: San Francisco, CA

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
  • Express, 48 States
  • Express (AK, HI)
$195.12
Seller since 2009

Feedback rating:

(10664)

Condition: New
New Book. Shipped from US within 10 to 14 business days. Established seller since 2000.

Ships from: Secaucus, NJ

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
$220.68
Seller since 2007

Feedback rating:

(23584)

Condition: New
BRAND NEW

Ships from: Avenel, NJ

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
Page 1 of 1
Showing All
Close
Sort by
Sending request ...

Overview

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:


  • key interplay between transporters and enzymes in drug metabolism and drug interactions
  • the integral role of pharmacogenetics in metabolism-based drug-drug interactions
  • in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction)
  • in silico approaches enabling structure-activity and structure-function studies
  • high-throughput screening and GLP methods for evaluating drug interactions in vitro
  • the use of transgenic animal models to evaluate drug interactions

Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Gregory Reed, PhD (University of Kansas Medical Center)
Description: The first edition of this book, published in 2002, addressed the conceptual basis of drug-drug interactions and the experimental approaches to their detection and characterization. The editor and authors have updated and expanded this collection of articles for this second edition.
Purpose: The goal is to provide a single source for presenting and supporting the pharmacokinetic concepts of drug-drug interactions and the various experimental approaches to the study of such interactions, using experimental platforms ranging from in silico to in humans. This is an important and necessary goal, and one that it meets. It should be noted, however, that the work focuses on pharmacokinetic, but not pharmacodynamic, interactions.
Audience: The book provides a useful collection of information and references for individuals involved in drug metabolism and pharmacokinetics studies, and also can serve as an introduction to the area for pharmacologists and toxicologists who work in other areas related to drug development, or even clinical pharmacology. Students and residents with some knowledge of pharmacokinetics and pharmacodynamics also could use this book as a primer and introduction to this field.
Features: This collection builds on the strength of the previous edition by updating many chapters and by adding new topics to more completely survey the field of drug-drug interactions. Both a strength and a weakness of the collected chapters is that each chapter can stand alone. While this proves a benefit as a reference, so readers can simply go to the chapter that is most relevant to their needs, it has the drawback that there is very little cross-referencing between chapters. There also is variability in the style and utility of chapters, because some are integrated presentations and explanations of topics and others tend more towards compilation-style reviews. The former seems more useful.
Assessment: Overall, this book will serve as a valuable teaching and reference work for those currently involved in or needing to learn about pharmacokinetic drug-drug interactions. The updates and expansion from the first edition warrant its addition to an existing library.
Read More Show Less

Product Details

  • ISBN-13: 9780849375934
  • Publisher: CRC Press
  • Publication date: 2/11/2008
  • Series: Drugs and the Pharmaceutical Sciences Series
  • Edition description: REV
  • Edition number: 2
  • Pages: 768
  • Product dimensions: 6.30 (w) x 9.00 (h) x 1.70 (d)

Meet the Author

A. DAVID RODRIGUES is Executive Director, Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ, and received his Ph.D. in Biochemistry from the University of Surrey, Guildford, UK. Dr. Rodrigues is a member of the American Association of Pharmaceutical Scientists and is presently serving on the Scientific Affairs Committee of the International Society for the Study of Xenobiotics. He has authored more than 75 peer-reviewed articles and over one dozen book chapters, and sits on the Editorial Board of three journals (Drug Metabolism and Disposition, Drug Metabolism Letters, and Current Drug Metabolism).

Read More Show Less

Table of Contents

Introducing Pharmacokinetics and Pharmacodynamic Concepts. In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes. Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions. UDP-Glucuronosyltransferases. Drug-Drug Interactions Involving the Membrane Transport Process. In Vitro Models for Studying Induction of Cytochrome P450 Enzymes. In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450. The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development. Cytochrome P450 Protein Modeling and Ligand Docking. The Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions. Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro-In Vivo Correlations. Transporter-mediated Drug Interactions: Molecular Mechanisms and Clinical Implications. Metabolism & Transport Drug Interaction Database: a web-based research and analysis tool. In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans. Drug-Drug Interactions: Clinical Perspective. An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective. Drug-Drug Interactions: Toxicological Perspectives. Drug-Drug Interactions: Marketing Perspectives.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)