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Doody's Review ServiceReviewer: Gregory Reed, PhD (University of Kansas Medical Center)
Description: The first edition of this book, published in 2002, addressed the conceptual basis of drug-drug interactions and the experimental approaches to their detection and characterization. The editor and authors have updated and expanded this collection of articles for this second edition.
Purpose: The goal is to provide a single source for presenting and supporting the pharmacokinetic concepts of drug-drug interactions and the various experimental approaches to the study of such interactions, using experimental platforms ranging from in silico to in humans. This is an important and necessary goal, and one that it meets. It should be noted, however, that the work focuses on pharmacokinetic, but not pharmacodynamic, interactions.
Audience: The book provides a useful collection of information and references for individuals involved in drug metabolism and pharmacokinetics studies, and also can serve as an introduction to the area for pharmacologists and toxicologists who work in other areas related to drug development, or even clinical pharmacology. Students and residents with some knowledge of pharmacokinetics and pharmacodynamics also could use this book as a primer and introduction to this field.
Features: This collection builds on the strength of the previous edition by updating many chapters and by adding new topics to more completely survey the field of drug-drug interactions. Both a strength and a weakness of the collected chapters is that each chapter can stand alone. While this proves a benefit as a reference, so readers can simply go to the chapter that is most relevant to their needs, it has the drawback that there is very little cross-referencing between chapters. There also is variability in the style and utility of chapters, because some are integrated presentations and explanations of topics and others tend more towards compilation-style reviews. The former seems more useful.
Assessment: Overall, this book will serve as a valuable teaching and reference work for those currently involved in or needing to learn about pharmacokinetic drug-drug interactions. The updates and expansion from the first edition warrant its addition to an existing library.