Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools / Edition 1

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Overview

Most drugs never leave the laboratory as a result of failure to predict efficacy and safety. In response, this book offers readers an array of new and emerging technologies. These technologies arm pharmaceutical scientists with more systematic and effective approaches for deciphering the complex interactions among chemistry, biology, and medicine, helping to ensure that more research efforts focus on drugs that can be successfully translated from the laboratory to the clinic and onto the market. Among the topics addressed in Drug Efficacy, Safety, and Biologics Discovery are: High throughput protein-based technologies and computational models for drug development, efficacy, toxicity, systems pharmacology, biomarkers, biomolecular networks, computational systems biology modeling of dosimetry, cellular response pathways, nanotechnology to improve drug delivery, and modeling efficacy and safety of engineered biologics
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Product Details

Meet the Author

Sean Ekins, MSc, PHD, DSc, is the Principal at Collaborations in Chemistry; and Adjunct Associate Professor in the Department of Pharmaceutical Sciences at the University of Maryland, School of Pharmacy. Dr. Ekins has published widely on ADME/Tox, systems biology, computational, and in vitro drug discovery approaches. He has previously edited two Wiley books: Computer Applications in Pharmaceutical Research and Development (2006) and Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals (2007).

Jinghai J. Xu, PHD, is Director of Automated Biotechnology at Merck. Previously he headed predictive toxicology at Pfizer, where he led research activities in drug-induced liver injury, genetic toxicology, drug transporters, assay development, high content screening, in vitro in vivo correlations, systems biology, and systems toxicology. Dr. Xu has served on steering committees of academic-industry and industry-industry collaborations, and as a guest lecturer at the Massachusetts Institute of Technology.

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Table of Contents

Pt. I Drug Efficacy and Safety Technology 1

1 Focus on Fundamentals: Towards Better Therapeutic Index Prediction Jinghai J. Xu Xu, Jinghai J. Li J. Yu Li, J. Yu 3

2 High-Throughput Protein-Based Technologies and Computational Models for Drug Development, Efficacy and Toxicity Leonidas G. Alexopoulos Alexopoulos, Leonidas G. Julio Saez-Rodriguez Saez-Rodriguez, Julio Christopher W. Espelin Espelin, Christopher W. 29

3 Cellular Systems Biology Applied to Preclinical Safety Testing: A Case Study of CellCiphr Profiling Lawrence Vernetti Vernetti, Lawrence William Irwin Irwin, William Kenneth A. Giuliano Giuliano, Kenneth A. Albert Gough Gough, Albert Kate Johnston Johnston, Kate D. Lansing Taylor Taylor, D. Lansing 53

4 Systems Pharmacology, Biomarkers, and Biomolecular Networks Aram Adourian Adourian, Aram Thomas N. Plasterer Plasterer, Thomas N. Raji Balasubramanian Balasubramanian, Raji Ezra G. Jennings Jennings, Ezra G. Shunguang Wang Wang, Shunguang Stephen Martin Martin, Stephen Jan van der Greef van der Greef, Jan Robert N. McBurney McBurney, Robert N. Pieter Muntendam Muntendam, Pieter Noubar B. Afeyan Afeyan, Noubar B. 75

5 Zebrafish Models for Human Diseases and Drug Discovery Hanbing Zhong Zhong, Hanbing Ning-Ai Liu Liu, Ning-Ai Shuo Lin Shuo, Lin 115

6 Toxicity Pathways and Models: Mining for Potential Side Effects Sean Ekins Ekins, Sean Josef Scheiber Scheiber, Josef 135

7 Computational Systems Biology Modeling of Dosimetry and Cellular Response Pathways Qiang Zhang Qiang, Zhang Yu-Mei Tan Tan, Yu-Mei Sudin Bhattacharya Bhattacharya, Sudin Melvin E. Andersen Andersen, Melvin E. 155

8 Stem Cell Technology for Embryotoxicity, Cardiotoxicity andHepatotoxicity Evaluation Julio C. Davila Davila, Julio C. Donald B. Stedman Stedman, Donald B. Sandra J. Engle Engle, Sandra J. Howard I. Pryor II Pryor, Howard I., II Joseph P. Vacanti Vacanti, Joseph P. 175

9 Telemetry Technology for Preclinical Drug Discovery and Development Yi Yang Yi, Yang 215

Pt. II Biologics Technology

10 Nanotechnology to Improve Drug Delivery Mayank D. Bhavsar Bhavsar, Mayank D. Shardool Jain Jain, Shardool Mansoor M. Amiji Amiji, Mansoor M. 231

11 Functional Glycomics and the Future of Glycomic Drugs Ram Sasisekharan Sasisekharan, Ram Karthik Viswanathan Viswanathan, Karthik 277

12 Modeling Efficacy and Safety of Engineered Biologics Jeffrey R. Chabot Chabot, Jeffrey R. Bruce Gomes Gomes, Bruce 301

13 Regulation of Gene Expression by Small, Non-Coding RNAs: Practical Applications Roman Herrara Herrara, Roman Eric Tien Tien, Eric 327

Pt. III Future Perspective

14 Future Perspectives of Biological Engineering in Pharmaceutical Research: The Paradigm of Modeling, Mining, Manipulation and Measurements Jinghai J. Xu Xu, Jinghai J. Sean Ekins Ekins, Sean Michael McGlashen McGlashen, Michael Douglas Lauffenburger Lauffenburger, Douglas 351

Index 381

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