Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
Used and New from Other Sellers
Used and New from Other Sellers
from $75.99
Usually ships in 1-2 business days
(Save 45%)
Other sellers (Hardcover)
  • All (8) from $75.99   
  • New (6) from $109.90   
  • Used (2) from $75.99   


Most drugs never leave the laboratory as a result of failure to predict efficacy and safety. In response, this book offers readers an array of new and emerging technologies. These technologies arm pharmaceutical scientists with more systematic and effective approaches for deciphering the complex interactions among chemistry, biology, and medicine, helping to ensure that more research efforts focus on drugs that can be successfully translated from the laboratory to the clinic and onto the market. Among the topics addressed in Drug Efficacy, Safety, and Biologics Discovery are: High throughput protein-based technologies and computational models for drug development, efficacy, toxicity, systems pharmacology, biomarkers, biomolecular networks, computational systems biology modeling of dosimetry, cellular response pathways, nanotechnology to improve drug delivery, and modeling efficacy and safety of engineered biologics
Read More Show Less

Product Details

Meet the Author

Sean Ekins, MSc, PHD, DSc, is the Principal at Collaborations in Chemistry; and Adjunct Associate Professor in the Department of Pharmaceutical Sciences at the University of Maryland, School of Pharmacy. Dr. Ekins has published widely on ADME/Tox, systems biology, computational, and in vitro drug discovery approaches. He has previously edited two Wiley books: Computer Applications in Pharmaceutical Research and Development (2006) and Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals (2007).

Jinghai J. Xu, PHD, is Director of Automated Biotechnology at Merck. Previously he headed predictive toxicology at Pfizer, where he led research activities in drug-induced liver injury, genetic toxicology, drug transporters, assay development, high content screening, in vitro in vivo correlations, systems biology, and systems toxicology. Dr. Xu has served on steering committees of academic-industry and industry-industry collaborations, and as a guest lecturer at the Massachusetts Institute of Technology.

Read More Show Less

Table of Contents

Pt. I Drug Efficacy and Safety Technology 1

1 Focus on Fundamentals: Towards Better Therapeutic Index Prediction Jinghai J. Xu Xu, Jinghai J. Li J. Yu Li, J. Yu 3

2 High-Throughput Protein-Based Technologies and Computational Models for Drug Development, Efficacy and Toxicity Leonidas G. Alexopoulos Alexopoulos, Leonidas G. Julio Saez-Rodriguez Saez-Rodriguez, Julio Christopher W. Espelin Espelin, Christopher W. 29

3 Cellular Systems Biology Applied to Preclinical Safety Testing: A Case Study of CellCiphr Profiling Lawrence Vernetti Vernetti, Lawrence William Irwin Irwin, William Kenneth A. Giuliano Giuliano, Kenneth A. Albert Gough Gough, Albert Kate Johnston Johnston, Kate D. Lansing Taylor Taylor, D. Lansing 53

4 Systems Pharmacology, Biomarkers, and Biomolecular Networks Aram Adourian Adourian, Aram Thomas N. Plasterer Plasterer, Thomas N. Raji Balasubramanian Balasubramanian, Raji Ezra G. Jennings Jennings, Ezra G. Shunguang Wang Wang, Shunguang Stephen Martin Martin, Stephen Jan van der Greef van der Greef, Jan Robert N. McBurney McBurney, Robert N. Pieter Muntendam Muntendam, Pieter Noubar B. Afeyan Afeyan, Noubar B. 75

5 Zebrafish Models for Human Diseases and Drug Discovery Hanbing Zhong Zhong, Hanbing Ning-Ai Liu Liu, Ning-Ai Shuo Lin Shuo, Lin 115

6 Toxicity Pathways and Models: Mining for Potential Side Effects Sean Ekins Ekins, Sean Josef Scheiber Scheiber, Josef 135

7 Computational Systems Biology Modeling of Dosimetry and Cellular Response Pathways Qiang Zhang Qiang, Zhang Yu-Mei Tan Tan, Yu-Mei Sudin Bhattacharya Bhattacharya, Sudin Melvin E. Andersen Andersen, Melvin E. 155

8 Stem Cell Technology for Embryotoxicity, Cardiotoxicity andHepatotoxicity Evaluation Julio C. Davila Davila, Julio C. Donald B. Stedman Stedman, Donald B. Sandra J. Engle Engle, Sandra J. Howard I. Pryor II Pryor, Howard I., II Joseph P. Vacanti Vacanti, Joseph P. 175

9 Telemetry Technology for Preclinical Drug Discovery and Development Yi Yang Yi, Yang 215

Pt. II Biologics Technology

10 Nanotechnology to Improve Drug Delivery Mayank D. Bhavsar Bhavsar, Mayank D. Shardool Jain Jain, Shardool Mansoor M. Amiji Amiji, Mansoor M. 231

11 Functional Glycomics and the Future of Glycomic Drugs Ram Sasisekharan Sasisekharan, Ram Karthik Viswanathan Viswanathan, Karthik 277

12 Modeling Efficacy and Safety of Engineered Biologics Jeffrey R. Chabot Chabot, Jeffrey R. Bruce Gomes Gomes, Bruce 301

13 Regulation of Gene Expression by Small, Non-Coding RNAs: Practical Applications Roman Herrara Herrara, Roman Eric Tien Tien, Eric 327

Pt. III Future Perspective

14 Future Perspectives of Biological Engineering in Pharmaceutical Research: The Paradigm of Modeling, Mining, Manipulation and Measurements Jinghai J. Xu Xu, Jinghai J. Sean Ekins Ekins, Sean Michael McGlashen McGlashen, Michael Douglas Lauffenburger Lauffenburger, Douglas 351

Index 381

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)