Drug Hepatoxicity, An Issue of Clinics in Liver Disease

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More About This Textbook


Drug hepatotoxicity is one of the current hot topics in hepatology and internal medicine for that matter. In the last 5 years, two drugs have been withdrawn for significant liver injury causing death or need for transplantation; additionally, others have not been approved and several have had black box warning labels placed due to concerns that the risk is small but significant for harmful outcomes. The present volume is intended to review our current understanding of the principles underlying our understanding of the problems associated with drug-related liver injury: what the pathogenetic mechanism are, how the condition is diagnosed, what drugs are associated with drug-induced liver injury and how these conditions present. The reader should be well-advised that there are few absolutes in this area and a lot of opinion but as we know more, we can be more careful about using drugs in our everyday practice of the best of 21st century medicine. This is a volume for anyone who regularly prescribes drugs for his/her patients and who is concerned enough to wish to avoid pitfalls in doing so.
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Product Details

  • ISBN-13: 9781416050506
  • Publisher: Elsevier Health Sciences
  • Publication date: 10/9/2007
  • Series: Clinics: Internal Medicine Series
  • Pages: 683
  • Product dimensions: 6.32 (w) x 9.10 (h) x 0.58 (d)

Table of Contents

Preface   William M. Lee     xi
Mechanisms of Drug-Induced Liver Disease   Basuki K. Gunawan   Neil Kaplowitz     459
Causality Assessment of Drug-Induced Hepatotoxicity: Promises and Pitfalls   Max A. Shapiro   James H. Lewis     477
Cancer Chemotherapy I: Hepatocellular Injury   Edmundo A. Rodriguez-Frias   William M. Lee     641
Cancer Chemotherapy II: Atypical Hepatic Injuries   Edmundo A. Rodriguez-Frias   William M. Lee     663
Index     677
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