Overview

This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an ...

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Drug-Induced Liver Disease

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Overview

This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.



  • A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease.

  • Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks.

  • Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition.

  • Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject. 

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Editorial Reviews

Doody's Review Service
Reviewer: Steven I. Shedlofsky, MD (University of Kentucky College of Medicine)
Description: This multiauthored book with over 50 contributors provides in-depth discussions of the liver toxicities of pharmaceutical agents in 30 chapters, with one of the chapters dealing with alternative medicine and another with occupational toxins. The chapters are loosely organized into sections on mechanisms of liver injury (10 chapters), diagnosis and management (2 chapters), hepatotoxicity of specific drugs (17 chapters), and regulatory perspectives (1 chapter).
Purpose: The purpose of the book is to provide an "authoritative, up-to-date volume" describing drug-induced liver disease that "will be of great interest to a broad audience." Considering the ever growing importance of drug therapy in clinical medicine, and that serious liver toxicity is the single most-common reason for drug withdrawals from the market, an accurate and current compendium of drug hepatotoxicities with an understanding of their basic mechanisms is quite important. Because most chapters are written by recognized experts, the contents as a whole provide excellent in-depth coverage of the topic.
Audience: But there is some concern as to whether the book is truly written for a "broad audience". This is not a reference book in the sense that one can easily access all the information about the liver toxicity of a particular agent in one place. And the range of information on each agent varies from very extensive descriptions to brief citations. This book is directed mainly to academic (and to a lesser extent private practice hepatologists) who do research and teach about hepatotoxicity and to whom patients are referred with drug-induced toxicities.
Features: The strength of this book is that it brings together in one place excellent discussions of drug-induced liver disease that are well referenced and well written. The histopathology chapter is particularly good with 53 figures of pathology and 15 tables. It's too bad these could not be in color. The last chapter on FDA regulatory policy is also very enlightening. A potential negative factor with regard to content is that there are very few references cited after 2000, suggesting that most chapters were written sometime in early 2001. Furthermore, because this book is multi-authored and has a section on mechanisms separate from effects of specific agents, there is a great deal of redundancy of information. This would not be a problem, except that the index fails to identify many cited pages and can't be depended on to find all the information on any particular drug or topic. Finally, there is great variability in how well various topics are covered.
Assessment: In summary, this book is a very worthy addition to the libraries of academic hepatologists, practicing hepatologists, and PhD liver investigators interested in hepatotoxicity. Although it might not serve well as a reference text, it is loaded with useful information and references. With its cost of $195, if one wanted a reference text, one might still consider the late Hy Zimmerman's 1999 text: Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals (ISBN 0781719526, $169).

3 Stars from Doody
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Product Details

  • ISBN-13: 9780123878182
  • Publisher: Elsevier Science
  • Publication date: 4/18/2013
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 3
  • Pages: 776
  • File size: 13 MB
  • Note: This product may take a few minutes to download.

Table of Contents

Part I. Mechanisms of Liver Injury Chapter 1: Drug-Induced Liver Injury: Introduction and Overview Chapter 2: Cytochrome P450 Activation of Toxins and Hepatotoxicity Chapter 3: Mechanistic Role of Acyl Glucuronides Chapter 4: Oxidative Stress, Antioxidant Defense and Liver Injury Chapter 5: Hepatotoxicity due to Mitochondrial Injury Chapter 6: Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity Chapter 7: Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis Chapter 8: Liver Sinusoidal Endothelial Cell and Liver Injury Chapter 9: Macrophages and Kupffer Cells in Hepatotoxicity Chapter 10: Role of Inflammation in Drug-Induced Liver Disease Chapter 11: Role of Adaptive Immune System Chapter 12: Role of Tissue Repair in Liver Injury Chapter 13: Genetic Factors in Pathogenesis

Part II. Diagnosis and Management Chapter 14: Clinical Manifestations and Management of Drug-Induced Liver Diseases Chapter 15: Histopathology of Drug-Induced Liver Disease Chapter 16: Risk Factors for Drug-Induced Liver Disease Chapter 17: The Promise of Genomics, Proteomics and Metabolomics of Blood and Liver in the Diagnosis of Drug-Induced Liver Disease Chapter 18: Causality Assessment

Part III. Hepatotoxicity of Specific Drugs Chapter 19: Mechanisms of Acetaminophen-Induced Liver Disease Chapter 20: Acetaminophen – Pathology and Clinical Presentation of Hepatotoxicity Chapter 21: Mechanisms Underlying the Hepatotoxicity of Non-Steroidal Anti-Inflammatory Drugs Chapter 22: Non-Steroidal Anti-Inflammatory Drugs – Pathology and Clinical Presentation of Hepatotoxicity Chapter 23: Mechanisms, Pathology and Clinical Presentation of Hepatotoxicity of Anesthetic Agents Chapter 24: Anticonvulsant AgentsChapter 25: Psychotropic Drugs and Drugs of Abuse Chapter 26: Hepatotoxicity of Antimicrobials and Antifungal Agents Chapter 27: Antituberculosis Agents Chapter 28: Hepatotoxicity in Antiviral Agents Chapter 29: Hepatotoxicity of Cardiovascular and Antidiabetic Drugs Chapter 30: Cancer Chemotherapy Chapter 31: Hepatotoxicity of Immunomodulating Agents and the Transplant Situation Chapter 32: Methotrexate Chapter 33: Hormones and Hormone Antagonists Chapter 34: Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis Chapter 35: Hepatotoxicity and Herbal Medicines, Vitamins and Natural Hepatoxins Chapter 36: Occupational and Environmental Hepatotoxicity Chapter 37: Chronic Liver Disease from Drugs

Part IV. Future Directions Chapter 38: Regulatory Perspectives Chapter 39: Drug-Induced Liver Injury Networks Chapter 40: Liver Tox: The Future

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