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Doody's Review ServiceReviewer: Melissa M. Ranieri, BS, PharmD (Temple University School of Pharmacy)
Description: This book describes thousands of drug-drug interactions, including the clinical significance of the drug interaction, a rating system for the risk of the interaction, and management options for clinicians prescribing or dispensing drugs in their practice.
Purpose: The purpose is to provide an analysis of drug interactions which can be used by clinicians who prescribe, dispense, or administer medications. For each listed interaction, the authors assess the published drug interaction literature and provide information on the predictability of the interaction. Information on the clinical significance of the interaction and how to minimize the risk of the interaction is also provided. A five-step classification system also indicates whether an intervention is needed to avoid the interaction. The authors' objectives are met in that the book provides clear and concise information on many drug-drug interactions. It provides the reader with clinically relevant information on each interaction, includes data from the literature to support the interaction, and lists management options to minimize the risk of the interaction.
Audience: The book is intended for any healthcare professional familiar with drugs and their use in modern-day medicine. It can be used by physicians who prescribe drugs, pharmacists who dispense drugs, or nurses who administer medications. It can also be used by students in any of these fields. It is particularly useful in everyday practice because it provides concise information in an easy-to-use format. The index provides a fast and easy way to look up a drug interaction alphabetically and also lists each interaction by a number which denotes the risk of the interaction and whether or not it should be avoided. It also provides practical information for the management options of the interaction. The authors of the book, Philip Hansten, PharmD, and John Horn, PharmD, are both recognized as experts in the field of drug interactions.
Features: For each drug interaction, there is a brief summary in bold describing the drug interaction and its clinical importance. It also includes risk factors for the interaction, if there are any (e.g., patients who are deficient in a certain isoenzyme, renal or liver impairment). It then goes on to describe the mechanism of the drug interaction. A clinical evaluation describes any pertinent information from the literature to support each interaction. Related drugs are listed which may interact in a similar way to the precipitant drug. Finally, management options are provided for the clinician to minimize the risk of the interaction and monitoring recommendations listed to help the clinician recognize the interaction. The book is helpful for clinicians because it provides concise and practical information on drug-drug interactions, a quick and easy way to look up a particular drug interaction, a rating system which denotes whether the interaction should be avoided or the risk minimized. It also includes nonprescription drugs as well, which is helpful because information on these drug interactions is not always easy to find. Finally, among the most helpful features book provides are management options to minimize the risk of the interaction.
Assessment: Updated editions are always needed because new drugs are always coming to market and new information on existing drugs and their interactions are often discovered. This is a very useful tool for clinicians dealing with medications in their practice.