Description: This drug reference provides organized, concise, and practical drug interaction monographs with information that can easily be applied in clinical practice. This update includes more drug interaction monographs, including prescription, nonprescription, and herbal products.
Purpose: It provides updated and pragmatic information for healthcare providers who prescribe, dispense, or administer medications. The drug interaction monographs are designed to provide information that can be easily referenced and used in daily patient care. The book provides recommendations to manage drug interactions as well as additional references for further evaluation of the interaction. It succeeds in providing accurate information that can be applied in clinical practice in order to avoid adverse outcomes due to drug interactions.
Audience: The book can be used by any healthcare professional who prescribes, dispenses or administers medications, including physicians, pharmacists, and nurses. The information can easily be applied to patient care because it is concise, easily referenced, and practical. The index also allows readers to quickly access information and provides a risk rating for each interaction. The editors are experts in the field of drug interactions.
Features: The helpful introductory chapter describes the different mechanisms of drug interactions and includes the time course of drug interactions, which is important for clinicians to know when to monitor for a potential effect. The various mechanisms for pharmacokinetic interactions also are outlined, with examples of each type. The examples provide clinical drug interactions which emphasize important concepts. Some examples, such as common drug inducers and inhibitors, are organized in table format which allows for easy reference. Newer concepts, such as grapefruit juice interactions and p-glycoprotein, which may not be familiar to some clinicians, are covered in the beginning of the book. The majority of the book is made up of drug interaction monographs, organized alphabetically by generic name. Each monograph provides a summary of the drug interaction, risk factors that increase the likelihood of the interaction, and the proposed mechanism. Studies supporting the interaction are summarized with references for further evaluation. Finally, and perhaps the most important information in the monograph, there is a recommendation for management of the interaction in order to avoid adverse outcomes, outlined using the five-step classification system provided by the Drug Interaction Foundation. According to this system, the drug interaction is assigned to one of five classes based on the action needed to minimize the risk of the interaction. Using this system is a logical and practical way to allow practitioners to apply the information to clinical practice.
Assessment: This book succeeds in providing accurate, updated, and practical information which healthcare professionals can easily access. The book differentiates itself from others on drug interactions with its classification system focused on managing the drug interaction. This information is critical in guiding readers in taking action to minimize adverse outcomes. These recommendations are supported by evidence, with references that allow readers to further explore published data on the potential interaction.