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Doody's Review ServiceReviewer: Raj Tummala, MD (Wyeth Pharmaceuticals)
Description: This is an up-to-date reference on the interactions of psychotropics with other drugs, guiding the clinician on avoiding potentially life-threatening adverse events. The book is a valuable resource and provides a wealth of information.
Purpose: The purpose is to provide a comprehensive review of psychotropic drug interactions for the prescriber.
Audience: It is targeted at anyone dealing with psychotropics such as students, residents, clinicians, nursing staff and psychopharmacologists.
Features: Drug interactions can lead to potentially fatal complications and can be avoided with some care. The authors of the third edition provide an updated review of the common drug interactions seen with the various classes of psychotropics. The section on the concepts and mechanisms of drug interactions is very well written and provides a succinct and clear review on pharmacokinetics. Information on the various classes is presented in a consistent format, although the format for antidepressants can be confusing initially, with the arrangement of the different classes of antidepressants. Each drug interaction has an explanation of the mechanism and clinical implications. In some cases, the authors cite case reports as well as any controlled studies. Information is augmented with the use of well-depicted tables and graphs that are easy to read. New to the current edition are dosing, drug dependence, drug-food interactions, and interactions with HIV medications as well as appendixes on herbal medication and cytochromes. The authors provide an extensive current reference section at the end of each chapter with a cross reference with the individual drugs. Of special mention is the index, which allows the clinician to navigate through the book. Overall, the authors have done an excellent job in covering the various classes of psychotropics.
Assessment: This is a very useful and easy-to-read update that clinicians can use in daily practice as a quick reference. The book is written in a clinically practical, user-friendly format differentiating itself from other books in this category. It is highly recommended for anyone dealing with psychotropics and patient care.