Drug Metabolism and Transport: Molecular Methods and Mechanisms / Edition 1

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Two key aspects of how the body handles drugs and other chemicals are metabolism and transport. The remarkable advances in molecular and cell biology and the development of novel in vitro model systems to study the various processes involved in metabolism and transport have expanded our knowledge and led to numerous, new therapeutic approaches to treatment of chemically-induced toxicity and disease. This book presents a collection of reviews on important topics in metabolism and transport. The editor has selected several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxtgenases, glutathione S-transferases, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present approaches to the study of signaling pathways in the regulation of drug metabolism enzymes and how modulation of these pathways can influence antiviral therapy. The transport chapters cover multidrug resistance proteins, the reduced folate carrier, and plasma membrane and mitochondrial glutathione transporters.

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Editorial Reviews

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"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society
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Product Details

  • ISBN-13: 9781588293244
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 9/24/2004
  • Series: Methods in Pharmacology and Toxicology Series
  • Edition description: 2005
  • Edition number: 1
  • Pages: 388
  • Sales rank: 1,373,733
  • Product dimensions: 0.88 (w) x 6.14 (h) x 9.21 (d)

Table of Contents

Renal Cyhrome P450s and Flavin-Containing Monooxygenases: Potential Roles in Metabolism and Toxicity of 1,3-Butadiene, Trichloroethylene, and Tetrachloroethylene Adnan A. Elfarra

Experimental Approaches for the Study of Cyhrome P450 Gene Regulation Hollie I. Swanson, Susan D. Kraner, Soma S. Ray, Martin Hoagland, Earl D. Thompson, Xinyu Zheng, and Yanan Tian

Insulin and Growth Factor Signaling: Effects on Drug-Metabolizing Enzymes Sang K. Kim, Kimberley J. Woodcroft, and Raymond F. Novak

Catalytic Function and Expression of Glutathione Transferase Zeta Philip G. Board, M. W. Anders, and Anneke C. Blackburn

Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases Anna Radominska-Pandya, Joanna M. Little, and Arthur Bull

Transcriptional Regulation of UDP- Glucuronosyltransferases Anna Radominska-Pandya, Peter I. Mackenzie, and Wen Xie

Phenotypic and Genotypic Characterization of N-Acetylation Craig K. Svensson and David W. Hein

Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen Sam A. Bruschi

Modulation of Drug Metabolism and Antiviral Therapies Bernhard H. Lauterburg

Modulation of Thiols and Other Low-Molecular-Weight Cofactors: Effects on Drug Metabolism and Disease Susceptibility Charles V. Smith

Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics Phillip M. Gerk and Mary Vore

Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier Wei Cao and Larry H. Matherly

Glutathione Transport in the Kidneys: Experimental Models, Mechanisms, and Methods Lawrence H. Lash

Human Cytosolic Sulfotransferases: Properties, Physiological Functions, and Toxicology Charles N. Falany


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