Drug Resistance in Leukemia and Lymphoma III / Edition 1

by G.J.L. Kaspers, R. Pieters, A.J.P. Veerman

Overview

Cellular drug resistance is a major limitation to the success of chemotherapy of leu­ kemia and lymphoma. The importance of this has now been recognized by both clinicians and scientists. It is of utmost importance to bridge the gap between laboratory and clinic in this field of research. This is the main purpose of the series of International Symposia on Drug Resistance in Leukemia and Lymphoma. These are held every three years in Am­ sterdam, The Netherlands, since 1992. This book contains the proceedings of the third of these meetings, organised in 1998. The book covers all important aspects of drug resistance in leukemia and lymphoma, both in the form of extensive reviews as in manuscripts describing original data. General mechanisms of resistance are discussed, including the drug resistance related proteins p­ glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much information is provided on apoptosis and its regulators, and on the results of cell culture drug resistance assays. Several papers focus on the modulation or circumvention of drug resistance.

Product Details

ISBN-13:	9780306460555
Publisher:	Springer US
Publication date:	09/30/1999
Series:	Advances in Experimental Medicine and Biology , #457
Edition description:	1999
Pages:	638
Product dimensions:	6.10(w) x 9.25(h) x 0.06(d)

Table of Contents

Section I. Drug Resistance Related Proteins and Glutathione.- Section II. Apoptosis and Cell Death Regulations.- Section III. Risk Factors and Cell Culture Assays.- Section IV. Antifolates.- Section V. Nucleoside Analogues and Growth Factors.- Section VI. Glucocorticoids.- Section VII. Asparaginase.

Editorial Reviews

Documents the 1998 meeting of an international symposium held every three years in Amsterdam to share recent research into cellular drug resistance to chemotherapy for the two types of cancer<-->a major limitation on the approach's success. The 69 contributions cover drug resistance and related proteins and glutathione, apoptosis and cell death regulation, risk factors and cell culture assays, antifolates, nucleoside analogues and growth factors, glucocorticoids, and asparaginase. Among specific topics are proteins related to multi-drug resistance in primary cutaneous lymphomas, activating apoptosis pathways by anti-cancer drugs, in-vitro cytotoxic drug activity and in-vivo pharmacokinetics in childhood acute myeloid leukemia, the expression of DNA mismatched repair proteins in acute lymphoblastic leukemia and normal bone marrow, and glucocorticoid-induced apoptosis. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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