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Doody's Review ServiceReviewer: M. Victor Nora, PharmD, PhD (Rush Medical College of Rush University)
Description: This book examines the synthesis, resolution, therapeutic, and toxicological consequences of chirality in drugs. This is a second edition, with new coverage in the areas of synthesis, resolution, and kinetics, and it has updated areas in chiral separation, protein binding, and FDA guidelines.
Purpose: This book is one of a continuing series of books entitled Clinical Pharmacology. It is aimed at pharmaceutical chemists, biologists, and clinicians who are interested in stereoisomerism of drugs. This book attempts to cover too broad an area and consequently spreads itself too thin. Because this is a contributed book the coverage tends vary. Some chapters try to cover an area on which multiple books have been written (e.g., chiral drug synthesis) and consequently produce too sparse acoverage. Other cha pters, though well written, appear to be aimed at a medical student learning basic pharmacology and therefore are too elementary for a medicinal chemist. Other than for several well-known examples, the clinical relevance of the use of either racemic mixtures or pure isomers as drugs is still largely investigational.
Audience: Because of the unevenness of coverage and the wide scope of the book, this a book in search of an audience. Different chapters would be appropriate for different audiences.
Features: The book is amply illustrated by black-and-white structures, chromatograms, graphs, and tables of varying quality. The chemical structures are well drawn, and the stereochemistry is easily identified, but some of the diagrams and graphs (e.g., p 289) appear to be hand drawn and detract from the general appearance. In some chromatograms (e.g., p.118), the originals have not been completely cleaned up for publication.
Assessment: The typeface is easily readable, and the index is detailed and satisfactory. As individual chapters some are well written and informative, but as a book it does not reach its stated goals. For a clinician there is very little that would be applicable to his or her practice.