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Drug Transporters: Molecular Characterization and Role in Drug Disposition [NOOK Book]

Overview

This book offers a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body. Since publication of the first edition, there have been significant advances in the field: new transporters have been identified, new regulatory pathways have been discovered, and sophisticated techniques for validating transport processes have been developed. These have led to a better understanding of the physiological roles and ...

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Drug Transporters: Molecular Characterization and Role in Drug Disposition

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Overview

This book offers a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body. Since publication of the first edition, there have been significant advances in the field: new transporters have been identified, new regulatory pathways have been discovered, and sophisticated techniques for validating transport processes have been developed. These have led to a better understanding of the physiological roles and clinical implications of these transporters.

Retaining the same basic format as its predecessor, the second edition of Drug Transporters:
Molecular Characterization and Role in Drug Disposition provides an overview of drug transporters and presents the principles of drug transport and associated techniques. Several new chapters are added and others are thoroughly updated or expanded. This new edition overviews drug transporters; including their function, regulation, and role in drug disposition and interactions, as well as experimental approaches for studying drug transport. As a result, this new edition reflects where the field is today and also gives a perspective on the directions for the foreseeable future.

• Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters
• Includes new chapters on multidrug and toxin extrusion proteins, placental transport, and in silico approaches in drug discovery
• Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials
• Provides material ranging from fundamental mechanisms to clinical outcomes, making the book useful for novice and the expert reader

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Product Details

  • ISBN-13: 9781118704981
  • Publisher: Wiley
  • Publication date: 7/7/2014
  • Series: Wiley Series in Drug Discovery and Development
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 2
  • Pages: 544
  • Sales rank: 1,092,451
  • File size: 22 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Guofeng You, PhD, is an Associate Professor at the Ernest Mario School of Pharmacy at Rutgers University.

Marilyn E. Morris, PhD, is a Professor of Pharmaceutical Sciences in the School of Pharmacy and Pharmaceutical Sciences and Associate Dean in the Graduate School at the University at Buffalo, State University of New York.

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Table of Contents

Contributors.

Preface.

1 Overview of Drug Transporter Families (Guofeng You and Marilyn E. Morris).

2 Organic Cation Transporters (Thomas J. Urban and Kathleen M. Giacomini).

3 Organic Cation/Carnitine Transporters (Ijaz A. Qureshi, Ihsan Elimrani, Ernest Seidman, and Grant Mitchell).

4 Organic Anion Transporters (Megha Nagle, David M. Truong, Vibha Bhatnagar, Gregory Kaler, Kevin T. Bush, Wei Wu, Satish A. Eraly, and Sanjay K. Nigam).

5 Organic Anion–Transporting Polypeptides (Rommel G. Tirona and Richard B. Kim).

6 Mammalian Oligopeptide Transporters (Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, and Gregory T. Knipp).

7 Monocarboxylate Transporters (Justin A. Spanier and Lester R. Drewes).

8 Nucleoside Transporters: CNTs and ENTs (Li Xia, Mingyan Zhou, and Joanne Wang).

9 Bile Acid Transporters (Jyrki J. Eloranta and Gerd A. Kullak-Ublick).

10 Multidrug Resistance Protein: P-Glycoprotein (Frances J. Sharom).

11 Multidrug Resistance Proteins of the ABCC Subfamily (Anne T. Nies, Maria Rius, and Dietrich Keppler).

12 Breast Cancer Resistance Protein (Robert W. Robey, Orsolya Polgar, John Deeken, Kenneth K. W. To, and Susan E. Bates).

13 Drug Transport in the Liver (Pieter Annaert, Brandon Swift, Jin Kyung Lee, and Kim L. R. Brouwer).

14 Drug Transport in the Brain (Patrick T. Ronaldson, Karlo Babakhanian, and Reina Bendayan).

15 Drug Transport in the Kidney (Naohiko Anzai and Hitoshi Endou).

16 Drug Transporters in the Intestine (Yaming Su and Patrick J. Sinko).

17 Regulation of Drug Transporter Activity (Mei Hong and Guofeng You).

18 Experimental Approaches to the Study of Drug Transporters (Yoshiyuki Kubo, Yukio Kato, and Akira Tsuji).

19 In Vitro–In Vivo Scale-up of Drug Transport Activities (Kazuya Maeda and Yuichi Sugiyama).

20 Age- and Gender-Related Differences in Xenobiotic Transporter Expression (Curtis D. Klaassen and Xingguo Cheng).

21 Polymorphisms of Drug Transporters and Clinical Relevance (Leslie W. Chinn, Jason M. Gow, and Deanna L. Kroetz).

22 Diet/Nutrient Interactions with Drug Transporters (Xiaodong Wang and Marilyn E. Morris).

23 Interplay of Drug Transporters and Enzymes on Hepatic Drug Processing (K. Sandy Pang, Huadong Sun, and Shanjun Liu).

24 Clinical Relevance: Drug–Drug Interactions, Pharmacokinetics, Pharmacodynamics, and Toxicity (Serena Marchetti, Roberto Mazzanti, Jos H. Beijnen, and Jan H. M. Schellens).

Index.

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