Drugs and the Human Body with Implicatons for Society / Edition 7

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Overview

For undergraduate-level courses in Chemistry, Biology, Sociology, and Criminal Justice, Drugs and the Human Body, Seventh Edition addresses the effects of high-use, high-abuse drugs in America in a timely and straightforward fashion. It reflects the most recent research on the most highly addictive drugs, including street, over-the-counter, and prescription drugs. It is designed to be easily accessible to the nonscience major, yet comprehensive enough for use by the practicing professional.

New topics covered in this edition:
  • The Future of Drug Discovery
  • Hormone Replacement Therapy
  • Internet Sales of Drugs
  • Drugs and Pregnancy
  • Women's Health
  • Club Drugs
  • Aspirin in the Prevention of Heart Attack and Stroke
  • COX-2 Inhibitors
  • Are Teens Too Smart for Drug Testing?
This edition also includes:
  • Timely information on the latest street and designer drugs and gives special attention to their composition, addictive potential, and withdrawal symptoms.
  • Extensive introductory chapters that address definitions, concepts, theories, and laws that can be applied generally to many drug categories; including over-the-counter and prescription drugs.
  • Over 300 in-chapter and end-of-chapter study questions.
  • Valuable reference tools — e.g., a glossary of over 200 terms; an appendix of chemical structures for 14 categories of pharmacologically active compounds: DAWN data summaries pinpointing which drugs are causing problems, where in America, and to whom.
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Product Details

  • ISBN-13: 9780131773219
  • Publisher: Prentice Hall
  • Publication date: 8/12/2003
  • Edition description: Subsequent
  • Edition number: 7
  • Pages: 512
  • Product dimensions: 6.99 (w) x 9.19 (h) x 0.99 (d)

Meet the Author

Ken Liska earned a Ph.D. in Pharmaceutical Chemistry from the University of Illinois and is a licensed pharmacist in that state. He taught college and university-level chemistry courses for 37 years. For 18 years his course Drugs and the Human Body drew hundreds of students at San Diego Mesa College. His scientific publications are in the areas of synthetic anti-cancer compounds and LSD analogs. Liska is also an Associate Editor of the Journal of Drug Education and Awareness. He lives in San Diego with his wife, Paula Meta Hoenecke Liska.

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Table of Contents

(NOTE: Each chapter ends with Web Sites and Study Questions.)

 1. The Magic Bullets.

 2. Where Drugs Come From.

 3. Federal Laws: The FDA and Drug Testing—Penalties for Illicit Use.

 4. What Happens to Drugs After We Take Them.

 5. Drugs at the Synapse.

 6. Narcotic Analgesics: Opiates and Opioids.

 7. Cocaine, Amphetamines, Caffeine, Nicotine, and Other Stimulants.

 8. The Barbiturates: Battered But Still Here.

 9. Alcohol and 100 Million Americans.

10. The Major and Minor Tranquilizers.

11. Marijuana.

12. Hallucinogens, Street Drugs, Designer Drugs, Club Drugs, Predatory Drugs, and Some Observations.

13. The Pill: An Update.

14. Non-Steroidal, Anti-Inflammatory Drugs (NSAIDs): Aspirin, Acetaminophen, Ibuprofen, Naproxen Sodium, Ketoprofen, Fenoprofen, and Celebrex and Vioxx.

15. Additional OTC Drugs and Chemicals.

16. Personal Drug Testing.

17. Drugs in Sports.

Appendix I: Structure-Activity Relationships (SARs).

Appendix II: Answers and Discussion: Understanding Alcoholism.

Appendix III: DAWN Data Summary.

Appendix IV: The Scientific Method.

Appendix V: Glossary.

Index.
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Preface

Attention, Students! You have in your hands a book loaded with facts about drugs in our culture. To obtain the most from it, I urge you to make use of the following aides:

  • More than 180 carefully selected Web sites (URLs) are included for your browsing. They are found in the text and at the ends of chapters. It is very important you type in the Web address exactly as shown. Here are 5 super introductory sites you can browse right away:
    alb2c3.com/drugs/
    http: //health.org (National Clearinghouse for Alcohol and Drug Information)
    usdoj.gov/dea/ (Drug Enforcement Administration)
    drugfreeamerica.org/drug_info.html
    nida.nih.gov/DrugPages/

    Of course, you may use your computer's search engines (such as Google, Mamma, or Lycos) to locate hundreds of additional Internet sites (I have given you many suggestions at the ends of certain chapters). You will soon learn that many of the sites you find are not valuable, and you must be selective.
  • Drugs in Sports is both the newest chapter (Chapter 17) and among the most pertinent to rampant drug use in America. This topic is now of major importance in America and throughout the world.
  • Women's Health and the importance of drugs therein is given greatly expanded coverage in this Seventh Edition. See the index for many facts, especially on unique drug responses and to obtain information from government sources.
  • For the chemistry-minded, Structure-Activity Relationships are presented in Appendix I. Learn about the chemical parts of molecules that engender pharmacological response.
  • If youneed help with words, a Glossary of over 200 terms will prove invaluable. Try it out (Appendix V).
  • Appendix II presents a 42-question self-test on understanding alcoholism, with answers and comments by experts in the field.
  • DAWN data summaries show us which drugs are causing problems, where in America they are prevalent, and to whom they represent a threat. See Appendix III and throughout the text.
  • Several dozen true case histories give us real-life examples of drug abuse. Topics range from an LSD trip to potheads to a failed diet plan.
  • Keyword listings and learning objectives at the beginning of each chapter provide focus, and in-chapter and end-of-chapter study questions will move you to reexamine the chapters and learn the material. Some of the study questions will ask you to take a stand on a drug or its effect on society. I urge you to equip yourself with the knowledge, state your position, and back it up with facts.
  • Check out the inside front and rear book covers for more drug data.

To the Professor: This new Seventh Edition edition features many enhancements and additions.

  • New is Section 2.7, The Future of Drug Discovery or "Drug Discovery 21st-Century Style." Drug discovery has been caught up in the great wave of technological change involving the human genome, the human proteome, the accompanying tools for research, and the support from computer-based Bioinformatics.
  • Hormone replacement therapy (HRT) is now included with estrogens in Section 2.5. HRT is a topic rife with research—so much so, in fact, that conclusions can be difficult to draw.
  • Complementary and alternative medicine (CAM) has become an important part of the nation's health system, and is now included in Section 1.3, with definitions and references for additional information.
  • Internet sales of drugs and devices is very big business, but the FDA and others have serious reservations about this practice, including counterfeit drugs (new in Section 3.9).
  • Drugs and pregnancy (Section 4.4) is new, as are the URL references.
  • Women's Health (Section 4.9) is given much greater emphasis in this Seventh Edition, with references to more information on the Internet and from government sources. The topic of Alcohol and Women is now in Section 9.4.
  • Club drugs, raves, and other current drugs of abuse are now emphasized in Chapter 12 generally and in Section 12.6, specifically.
  • Aspirin in the Prevention of Heart Attack and Stroke (Section 14.5) has been brought up to date with new research reports.
  • The discussion of COX-2 inhibitors has been expanded with new reports and Internet references (Section 14.10).
  • New is Section 16.10, Are Teens Too Smart for Drug Testing?
  • Throughout the text, many other topics have been added or updated, including circadian rhythms (Section 4.6), placebo (Section 1.3), drug addiction (1.4), generic drugs (1.10), ephedra (2.3), phytoestrogens (2.5), the search for anti-AIDS drugs (2.8), children's drugs (4.6), drug interactions (4.7), synaptic transmitters (5.7), nicotine (7.17), the chemical treatment of alcoholism (9.10), marijuana and hashish (11.1), marijuana as medicine (11.7), diet aids (15.12), and hydroxyethylstarch in sports (17.2). NIDA data are updated throughout the text. Note that all the URLs in the previous edition were searched, defunct sites discarded, and many new sites added; this applies to all in-text and end-of-chapter URLs.

A Seventh Edition Instructor's Manual (IM) is available gratis to adopters of this text. The IM provides a 725-question Test Bank, with all answers included; answers to all in-chapter and end-of-chapter questions for all 17 chapters; many more Web sites; a listing of approximately 100 federal and national organizations and resource centers related to drug information (via telephone, e-mail, and URLs); and several dozen newsletters and references. In addition, relevant publications and agencies are supplied specifically for each chapter.

This book can be used in general health and drug education classes, counselor training, parent groups, and allied health fields in general—nursing, dental hygiene, medical technology, physical therapy, occupational therapy, medical records, and industrial hygiene.

As before, most drugs have been selected for inclusion on the basis of their high potential for abuse and misuse or their dramatic effect upon contemporary North American society. I discuss prescription drugs, over-the-counter drugs, street drugs, and recreational drugs.

This book provides facts about drug sources, history, action in the body, side effects, interactions, tolerance, abuse potential, dosage, dependency, drug delivery systems, and alternatives to drugs in use today. Students appear eager to discuss the impact of drugs on their lives, and this book provides a host of golden opportunities. Consider drug dependence (Chapter 1); quackery (Chapter 3); drugs and sex (Chapter 4); drugs and stress (Chapter 5); pain killers (Chapter 6); cocaine and amphetamines (Chapter 7); the fetal alcohol syndrome and lowering the drinking age (Chapter 9); what marijuana does to the body (Chapter 11); the resurgence of LSD and look-alike drugs (Chapter 12); oral contraceptives for men (Chapter 13); personal drug testing (Chapter 16); and drugs in sports (Chapter 17).

I have furnished brief histories of a number of topics, including the development of insulin, the discovery of the ergot alkaloids, and the use of LSD in America. I believe that the history of drugs is fascinating—and, as in the case of cancer quackery and the origin of the food, drug, and cosmetic laws—often highly instructive and personally useful.

Chapters 1-5 address definitions, concepts, theories, laws, and procedures that can be applied generally to many drug categories. For example, in Chapter 4, I discuss how drugs are administered, how they are distributed throughout the body, and what eventually happens to them. In this chapter, the concepts of drug life, drug metabolism, and interactions help explain how drug action can persist in the body and how drugs can have unexpected actions.

Assuming that the reader has little or no background in science, I have used few chemical formulas. For the student who has the necessary background, however, Appendix I provides a challenging study of structure-activity relationships of fourteen pharmacological classes of drugs. A glossary is provided in Appendix V for those who are concerned about nomenclature.

Reader involvement in the text is encouraged by in-text problems and end-of-chapter questions and by means of a 42-question self-test on alcoholism (with answers and discussion in Appendix II). Also, in Chapter 1, students are given the chance to establish a beginning vocabulary of physiology terms and to become familiar with the metric system.

Read More Show Less

Introduction

Attention, Students! You have in your hands a book loaded with facts about drugs in our culture. To obtain the most from it, I urge you to make use of the following aides:

  • More than 180 carefully selected Web sites (URLs) are included for your browsing. They are found in the text and at the ends of chapters. It is very important you type in the Web address exactly as shown. Here are 5 super introductory sites you can browse right away:
    alb2c3.com/drugs/
    health.org (National Clearinghouse for Alcohol and Drug Information)
    usdoj.gov/dea/ (Drug Enforcement Administration)
    drugfreeamerica.org/drug_info.html
    nida.nih.gov/DrugPages/

    Of course, you may use your computer's search engines (such as Google, Mamma, or Lycos) to locate hundreds of additional Internet sites (I have given you many suggestions at the ends of certain chapters). You will soon learn that many of the sites you find are not valuable, and you must be selective.
  • Drugs in Sports is both the newest chapter (Chapter 17) and among the most pertinent to rampant drug use in America. This topic is now of major importance in America and throughout the world.
  • Women's Health and the importance of drugs therein is given greatly expanded coverage in this Seventh Edition. See the index for many facts, especially on unique drug responses and to obtain information from government sources.
  • For the chemistry-minded, Structure-Activity Relationships are presented in Appendix I. Learn about the chemical parts of molecules that engender pharmacological response.
  • If you need help with words, a Glossary of over 200 terms will prove invaluable. Try it out(Appendix V).
  • Appendix II presents a 42-question self-test on understanding alcoholism, with answers and comments by experts in the field.
  • DAWN data summaries show us which drugs are causing problems, where in America they are prevalent, and to whom they represent a threat. See Appendix III and throughout the text.
  • Several dozen true case histories give us real-life examples of drug abuse. Topics range from an LSD trip to potheads to a failed diet plan.
  • Keyword listings and learning objectives at the beginning of each chapter provide focus, and in-chapter and end-of-chapter study questions will move you to reexamine the chapters and learn the material. Some of the study questions will ask you to take a stand on a drug or its effect on society. I urge you to equip yourself with the knowledge, state your position, and back it up with facts.
  • Check out the inside front and rear book covers for more drug data.

To the Professor: This new Seventh Edition edition features many enhancements and additions.

  • New is Section 2.7, The Future of Drug Discovery or "Drug Discovery 21st-Century Style." Drug discovery has been caught up in the great wave of technological change involving the human genome, the human proteome, the accompanying tools for research, and the support from computer-based Bioinformatics.
  • Hormone replacement therapy (HRT) is now included with estrogens in Section 2.5. HRT is a topic rife with research--so much so, in fact, that conclusions can be difficult to draw.
  • Complementary and alternative medicine (CAM) has become an important part of the nation's health system, and is now included in Section 1.3, with definitions and references for additional information.
  • Internet sales of drugs and devices is very big business, but the FDA and others have serious reservations about this practice, including counterfeit drugs (new in Section 3.9).
  • Drugs and pregnancy (Section 4.4) is new, as are the URL references.
  • Women's Health (Section 4.9) is given much greater emphasis in this Seventh Edition, with references to more information on the Internet and from government sources. The topic of Alcohol and Women is now in Section 9.4.
  • Club drugs, raves, and other current drugs of abuse are now emphasized in Chapter 12 generally and in Section 12.6, specifically.
  • Aspirin in the Prevention of Heart Attack and Stroke (Section 14.5) has been brought up to date with new research reports.
  • The discussion of COX-2 inhibitors has been expanded with new reports and Internet references (Section 14.10).
  • New is Section 16.10, Are Teens Too Smart for Drug Testing?
  • Throughout the text, many other topics have been added or updated, including circadian rhythms (Section 4.6), placebo (Section 1.3), drug addiction (1.4), generic drugs (1.10), ephedra (2.3), phytoestrogens (2.5), the search for anti-AIDS drugs (2.8), children's drugs (4.6), drug interactions (4.7), synaptic transmitters (5.7), nicotine (7.17), the chemical treatment of alcoholism (9.10), marijuana and hashish (11.1), marijuana as medicine (11.7), diet aids (15.12), and hydroxyethylstarch in sports (17.2). NIDA data are updated throughout the text. Note that all the URLs in the previous edition were searched, defunct sites discarded, and many new sites added; this applies to all in-text and end-of-chapter URLs.

A Seventh Edition Instructor's Manual (IM) is available gratis to adopters of this text. The IM provides a 725-question Test Bank, with all answers included; answers to all in-chapter and end-of-chapter questions for all 17 chapters; many more Web sites; a listing of approximately 100 federal and national organizations and resource centers related to drug information (via telephone, e-mail, and URLs); and several dozen newsletters and references. In addition, relevant publications and agencies are supplied specifically for each chapter.

This book can be used in general health and drug education classes, counselor training, parent groups, and allied health fields in general--nursing, dental hygiene, medical technology, physical therapy, occupational therapy, medical records, and industrial hygiene.

As before, most drugs have been selected for inclusion on the basis of their high potential for abuse and misuse or their dramatic effect upon contemporary North American society. I discuss prescription drugs, over-the-counter drugs, street drugs, and recreational drugs.

This book provides facts about drug sources, history, action in the body, side effects, interactions, tolerance, abuse potential, dosage, dependency, drug delivery systems, and alternatives to drugs in use today. Students appear eager to discuss the impact of drugs on their lives, and this book provides a host of golden opportunities. Consider drug dependence (Chapter 1); quackery (Chapter 3); drugs and sex (Chapter 4); drugs and stress (Chapter 5); pain killers (Chapter 6); cocaine and amphetamines (Chapter 7); the fetal alcohol syndrome and lowering the drinking age (Chapter 9); what marijuana does to the body (Chapter 11); the resurgence of LSD and look-alike drugs (Chapter 12); oral contraceptives for men (Chapter 13); personal drug testing (Chapter 16); and drugs in sports (Chapter 17).

I have furnished brief histories of a number of topics, including the development of insulin, the discovery of the ergot alkaloids, and the use of LSD in America. I believe that the history of drugs is fascinating--and, as in the case of cancer quackery and the origin of the food, drug, and cosmetic laws--often highly instructive and personally useful.

Chapters 1-5 address definitions, concepts, theories, laws, and procedures that can be applied generally to many drug categories. For example, in Chapter 4, I discuss how drugs are administered, how they are distributed throughout the body, and what eventually happens to them. In this chapter, the concepts of drug life, drug metabolism, and interactions help explain how drug action can persist in the body and how drugs can have unexpected actions.

Assuming that the reader has little or no background in science, I have used few chemical formulas. For the student who has the necessary background, however, Appendix I provides a challenging study of structure-activity relationships of fourteen pharmacological classes of drugs. A glossary is provided in Appendix V for those who are concerned about nomenclature.

Reader involvement in the text is encouraged by in-text problems and end-of-chapter questions and by means of a 42-question self-test on alcoholism (with answers and discussion in Appendix II). Also, in Chapter 1, students are given the chance to establish a beginning vocabulary of physiology terms and to become familiar with the metric system.

Read More Show Less

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