Drugs,Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery / Edition 1

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Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the reninrugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the renin
Chapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and unique feature of this book is that a commentary on each chapter, written by an independent peer or peers, is included to present alternative views, greater depth and a different perspective. Clinicians and researchers alike will find this volume a stimulating, and perhaps even entertaining, addition to their libraries. .

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Stephen F. Vatner
In summary, this important and timely book is the most comprehensive text on this subject available to date. The broad scope of this volume makes it required reading for clinicians, physiologists and molecular biologists, who are seeking the current frontiers of the RAS in basic science and clinical medicine.
Christine Seidman
Represents a substantial contribution not only to the research community, but to the clinicians struggling to keep abreast of what the medical biologists are achieving at such a rapid pace.
The first volume of the series is partly developed from a July 1998 international symposium at the Victor Chang Cardiac Research Institute in Sydney Australia, and celebrates the centenary of the discovery of renin. The 18 contributions, with critical commentary on each by an independent investigator, focus on contemporary, controversial, and unresolved issues relating to the physiology of angiotensin II; the molecular basis for angiotensin II receptor structure, function, and regulation; the elucidation of pathophysiological mechanisms through ACE inhibition and gene knockouts; and the biochemistry and cellular and molecular biology of angiotensin-forming enzymes. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9789058230386
  • Publisher: Taylor & Francis
  • Publication date: 2/23/2000
  • Series: Victor Chang Molecular Cardiology Ser.
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 420
  • Product dimensions: 7.10 (w) x 10.00 (h) x 0.96 (d)

Table of Contents

Part I: Physiology of Angiotensin II
1. The Renin-Angiotensin System and Cardiovascular Homeostasis 2. Angiotensin II Receptors in Central Nervous System Physiology 3. Current Opinions on the Involvement of Angiotensin II in Hydromineral Balance 4.
Angiotensin II Effects on Reproductive Biology: Physiology or Pharmacological Curiosity? 5. Physiological Insights Derived from Mapping the Distributions of Angiotensin Receptors
Part II: Molecular Basis for Angiotensin II Receptor Structure, Function and Regulation
1. Conformational Theories on Receptor Activation from Studies of the AT1 Receptor 2. Control of Angiotensin II Action Through Receptor Regulation
Part III: Elucidation of Pathophysiological Mechanisms Through ACE Inhibition, AT1 Receptor Antagonism and Gene Knockouts
1. Clinical Applications and Limitations in the use of AT1-Receptor Antagonists 2. Implications for the Pathophysiology of Hypertension and Heart Failure Derived from Clinical Experience with Drugs 3. Modifying the Renin-Angiotensin System-Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Antagonists 4.
Clinical Trials of ACE Inhibitors: Pathogenetic Insights and Therapeutic Advances 5. Targeted Interruption of the Renin-Angiotensin System
Part IV: Angiotensin Forming Enzymes: Biochemistry, Cellular and Molecular Biology
1. Renin Secretion: Old Concepts and New Theories 2. Understanding the Regulation of Renin Gene Expression Through in vitro and in vivo Models 3. Three-Dimensional Structure and Substrate Specificity of Renin
Regulation of ACE Expression: One Gene, Two Enzymes 4. ACE in the Normal and Injured Heart: Where, What and Why? 5. Chymase: A Critical Evaluation of its Role in Angiotensin II Formation and Cardiovascular Disease 6. Kallikrein: Physiological Role in Angiotensin Formation Molecular Basis for Angiotensin II Receptor Structure, Function and Regulation Part III: Elucidation of Pathophysiological Mechanisms Through ACE Inhibition, AT1 Receptor Antagonism and Gene Knockouts Part IV: Angiotensin Forming Enzymes: Biochemistry, Cellular and Molecular Biology

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