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Dubois' Lupus Erythematosus / Edition 7

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Overview

Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.

This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors--twenty of them new to this edition--provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

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Editorial Reviews

John A. Robinson
This new edition encompasses putative etiologies, clinical course, and treatment of systemic lupus erythematosus (SLE). Unique aspects of the book are an unusual alphabetized bibliography and patient/health provider resources. The previous edition was published in 1987. Its purpose is to centralize the existing body of knowledge pertinent to SLE. SLE is a common and, in some instances, a highly morbid disease, so a centralized source of knowledge concerning it would be a worthy goal. This book meets the objectives in part, but the attempt to provide all existing facts relevant to SLE, however relevant or irrelevant, attenuates the book's user-friendliness. Rheumatologists/nephrologists and internists appear to be the targeted audiences. Some, but not all rheumatologists, will be seriously interested in a encyclopedic text that describes a disease of moderate interest. The two authors are highly credible authorities; however, the credibility of some of the contributors is less striking. The illustrations are adequate with average pedagogic value. Although some might think that it is impossible to overreference a book, this text disputes that belief. The unique features include a useful patient and health care provider guide to SLE. There is no question that SLE is an interesting disease, but does it merit a text of this magnitude? Moreover, because there have been no dramatic leaps in understanding of its pathogenesis, and the clinical course has not drastically changed, the need for an expanded new edition is not compelling. In a general sense, this edition misses a golden opportunity to present new or provocative concepts of SLE causation, but instead it dwells on overworked variationsof immune complex etiology and long existing animal models, neither of which will provide significant clarity of insight into the disease. There has been no attempt to cull the wheat from the chaff. The result is an encyclopedic body of citations, apparently encompassing all SLE writing, past or present, within this galaxy. This book represents a well-meaning attempt to provide a central source of the body pertinent to SLE. The senior author is an excellent writer; he should strongly consider revamping the next edition to reflect his vast experience and delete the bells and whistles.
Booknews
A reference for professionals, offering the latest information on the disease. Contains sections on the history of lupus; definition, classification, and epidemiology; the pathogenesis of lupus; autoantibodies; cutaneous lupus; clinical and laboratory features; and management and prognosis. Includes a patient's guide to the disease, and listings of resources for patients and physicians. Important changes to this fifth edition include chapter references rather than an all-inclusive bibliography, and color photos. New areas covered include neuroendocrine-immune links, osteoporosis, mouse genetics, and adhesion molecules, with expanded material on subjects including hormonal therapies, allergies, and outcome measures. Annotation c. by Book News, Inc., Portland, Or.
Booknews
The fourth edition of this premier reference in the field represents a major expansion of the third edition of 1987. The number of chapters has been increased from 24 to 62, including the writings of 39 new contributors, 53 in all. The basic science section has doubled in length and incorporates new sections covering genetics, tolerance, B and T lymphocytes, cytokines, natural killer cells, arachidonic acid metabolites, idiotype networks, and sex hormones. Auto-antibody chapters have increased from three to 11. The clinical section includes new chapters on pediatric rheumatology, infection, and supportive management. The alphabetized bibliography, long a unique feature of the Dubois texts, has been complemented with an author and subject index. The number of references cited has increased from 5,000 to some 9,000. Note: an incorrect ISBN is printed on the back cover. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: John A. Robinson, MD (Loyola University Stritch School of Medicine)
Description: This new edition encompasses putative etiologies, clinical course, and treatment of systemic lupus erythematosus (SLE). Unique aspects of the book are an unusual alphabetized bibliography and patient/health provider resources. The previous edition was published in 1987.
Purpose: Its purpose is to centralize the existing body of knowledge pertinent to SLE. SLE is a common and, in some instances, a highly morbid disease, so a centralized source of knowledge concerning it would be a worthy goal. This book meets the objectives in part, but the attempt to provide all existing facts relevant to SLE, however relevant or irrelevant, attenuates the book's user-friendliness.
Audience: Rheumatologists/nephrologists and internists appear to be the targeted audiences. Some, but not all rheumatologists, will be seriously interested in a encyclopedic text that describes a disease of moderate interest. The two authors are highly credible authorities; however, the credibility of some of the contributors is less striking.
Features: The illustrations are adequate with average pedagogic value. Although some might think that it is impossible to overreference a book, this text disputes that belief. The unique features include a useful patient and health care provider guide to SLE.
Assessment: There is no question that SLE is an interesting disease, but does it merit a text of this magnitude? Moreover, because there have been no dramatic leaps in understanding of its pathogenesis, and the clinical course has not drastically changed, the need for an expanded new edition is not compelling. In a general sense, this edition misses a golden opportunity to present new or provocative concepts of SLE causation, but instead it dwells on overworked variations of immune complex etiology and long existing animal models, neither of which will provide significant clarity of insight into the disease. There has been no attempt to cull the wheat from the chaff. The result is an encyclopedic body of citations, apparently encompassing all SLE writing, past or present, within this galaxy. This book represents a well-meaning attempt to provide a central source of the body pertinent to SLE. The senior author is an excellent writer; he should strongly consider revamping the next edition to reflect his vast experience and delete the bells and whistles.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780781793940
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 11/1/2006
  • Edition description: Seventh Edition
  • Edition number: 7
  • Pages: 1440
  • Product dimensions: 8.60 (w) x 10.90 (h) x 2.20 (d)

Table of Contents

HISTORY AND DEFINITIONS: Historical Background of Discoid & Systemic Lupus Erythematosus / Definition & Classification of Systemic Lupus Erythematosus / Environmental Aspects of Lupus / Epidemiology of Systemic Lupus Erythematosus

PATHOGENESIS: Pathogenesis of Systemic Lupus Erythematosus / Genetics of Human Lupus / Genetics of Murine Systemic Lupus Erythematosus / Apoptosis / Interaction of T Cells with Cells of the Innate Immune System & B Cells in the Pathogenesis of SLE / Cytokines & Interferons in Lupus / B Cells in Systemic Lupus Erythematosus / Abnormalities in Immune Complex Clearance & Fcγ Receptor Function / Complement & Systemic Lupus Erythematosus / Mechanisms of Acute Inflammation & Vascular Injury in Systemic Lupus Erythematosus / Idiotypes & Idiotype Networks / The Importance of Sex Hormones in Systemic Lupus Erythematosus / Neuroendocrine Immune Interactions: Principles & Relevance to Systemic Lupus Erythematosus / Animal Models of Systemic Lupus Erythematosus / Pathogenesis of Atherosclerosis in Lupus / Autoantigens & Defects in Immune Tolerance in Lupus

AUTOANTIBODIES: Structure & Derivation of Antibodies & Autoantibodies / Antinuclear Antibodies: An Overview / Antibodies to DNA / Antibodies to Histones & Nucleosome-Related Antigens / Antibodies to Ro/SSA & La/SSB / Antibodies to Spliceosomal Components / The Lupus Anticoagulant & Antiphospholipid Antibodies / Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus

THE SKIN IN LUPUS: Pathomechanisms of Cutaneous Lupus Erythematosus / Lupus-Specific Skin Disease (Cutaneous LE) / Lupus-Nonspecific Skin Disease

CLINICAL ASPECTS OF LUPUS: Clinical Presentation of Systemic Lupus Erythematosus / The Musculoskeletal System / Cardiovascular Manifestations of Lupus / Pulmonary Manifestations of Systemic Lupus Erythematosus / Clinical Aspects of Vasculitis & Selected Cutaneovascular Manifestations of Systemic Lupus Erythematosus / The Nervous System / Psychopathology of Lupus & Neuroimaging / Head & Neck Findings in Systemic Lupus Erythematosus: Manifestations Involving the Eye, Ear & Larynx / Ocular, Aural & Oral Manifestations / Hematologic & Lymphoid Abnormalities in Systemic Lupus Erythematosus / Gastrointestinal & Hepatic Manifestations / Systemic Lupus Erythematosus in Childhood & Adolescence / Drug-Induced Lupus / Infections in Systemic Lupus Erythematosus / Serum & Plasma Protein Abnormalities & Other Clinical Laboratory Determinations in Systemic Lupus Erythematosus / Clinical Indices in the Assessment of Lupus / Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus / Differential Diagnosis & Disease Associations / Mixed Connective Tissue Disease & Overlap Syndromes / The Mother in Systemic Lupus Erythematosus / The Fetus in Systemic Lupus Erythematosus / Neonatal Lupus / Reproductive Issues in Women with Autoimmune Disease / Lupus Nephritis: Pathology & Pathogenesis / Clinical & Laboratory Features of Lupus Nephritis

MANAGEMENT OF LUPUS: Principles of Therapy & Local Measures / Nonsteroidals & Salicylates for Systemic Lupus Erythematosus / Antimalarial Therapies / Systemic Glucocorticoid Therapy in Systemic Lupus Erythematosus / Immunosuppressive Drug Therapy / Nonpharmacologic & Complementary Therapeutic Modalities / Fibromyalgia in SLE & Use of Complementary & Alternative Medicine in SLE / Hormones & Gender-Related Issues / Clinical & Management Aspects of the Antiphospholipid Antibody Syndrome / Additional Therapies Used in the Management of Lupus / Adjunctive Measures & Issues: Allergies, Antibiotics, Vaccines & Disability / Issues in Drug Development in SLE: Clinical Trial Design, Outcome Measures & Biomarkers / Prognosis, Mortality & Morbidity in Systemic Lupus Erythematosus / Biologics & Stem Cell Therapies for Lupus

Appendix I. A Patient's Guide to Lupus Erythematosus
Appendix II. Lupus Resources

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