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Dubois' Lupus Erythematosus

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Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.

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Overview

Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.

This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors--twenty of them new to this edition--provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

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Editorial Reviews

John A. Robinson
This new edition encompasses putative etiologies, clinical course, and treatment of systemic lupus erythematosus (SLE). Unique aspects of the book are an unusual alphabetized bibliography and patient/health provider resources. The previous edition was published in 1987. Its purpose is to centralize the existing body of knowledge pertinent to SLE. SLE is a common and, in some instances, a highly morbid disease, so a centralized source of knowledge concerning it would be a worthy goal. This book meets the objectives in part, but the attempt to provide all existing facts relevant to SLE, however relevant or irrelevant, attenuates the book's user-friendliness. Rheumatologists/nephrologists and internists appear to be the targeted audiences. Some, but not all rheumatologists, will be seriously interested in a encyclopedic text that describes a disease of moderate interest. The two authors are highly credible authorities; however, the credibility of some of the contributors is less striking. The illustrations are adequate with average pedagogic value. Although some might think that it is impossible to overreference a book, this text disputes that belief. The unique features include a useful patient and health care provider guide to SLE. There is no question that SLE is an interesting disease, but does it merit a text of this magnitude? Moreover, because there have been no dramatic leaps in understanding of its pathogenesis, and the clinical course has not drastically changed, the need for an expanded new edition is not compelling. In a general sense, this edition misses a golden opportunity to present new or provocative concepts of SLE causation, but instead it dwells on overworked variationsof immune complex etiology and long existing animal models, neither of which will provide significant clarity of insight into the disease. There has been no attempt to cull the wheat from the chaff. The result is an encyclopedic body of citations, apparently encompassing all SLE writing, past or present, within this galaxy. This book represents a well-meaning attempt to provide a central source of the body pertinent to SLE. The senior author is an excellent writer; he should strongly consider revamping the next edition to reflect his vast experience and delete the bells and whistles.
Booknews
A reference for professionals, offering the latest information on the disease. Contains sections on the history of lupus; definition, classification, and epidemiology; the pathogenesis of lupus; autoantibodies; cutaneous lupus; clinical and laboratory features; and management and prognosis. Includes a patient's guide to the disease, and listings of resources for patients and physicians. Important changes to this fifth edition include chapter references rather than an all-inclusive bibliography, and color photos. New areas covered include neuroendocrine-immune links, osteoporosis, mouse genetics, and adhesion molecules, with expanded material on subjects including hormonal therapies, allergies, and outcome measures. Annotation c. by Book News, Inc., Portland, Or.
Booknews
The fourth edition of this premier reference in the field represents a major expansion of the third edition of 1987. The number of chapters has been increased from 24 to 62, including the writings of 39 new contributors, 53 in all. The basic science section has doubled in length and incorporates new sections covering genetics, tolerance, B and T lymphocytes, cytokines, natural killer cells, arachidonic acid metabolites, idiotype networks, and sex hormones. Auto-antibody chapters have increased from three to 11. The clinical section includes new chapters on pediatric rheumatology, infection, and supportive management. The alphabetized bibliography, long a unique feature of the Dubois texts, has been complemented with an author and subject index. The number of references cited has increased from 5,000 to some 9,000. Note: an incorrect ISBN is printed on the back cover. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: John A. Robinson, MD (Loyola University Stritch School of Medicine)
Description: This new edition encompasses putative etiologies, clinical course, and treatment of systemic lupus erythematosus (SLE). Unique aspects of the book are an unusual alphabetized bibliography and patient/health provider resources. The previous edition was published in 1987.
Purpose: Its purpose is to centralize the existing body of knowledge pertinent to SLE. SLE is a common and, in some instances, a highly morbid disease, so a centralized source of knowledge concerning it would be a worthy goal. This book meets the objectives in part, but the attempt to provide all existing facts relevant to SLE, however relevant or irrelevant, attenuates the book's user-friendliness.
Audience: Rheumatologists/nephrologists and internists appear to be the targeted audiences. Some, but not all rheumatologists, will be seriously interested in a encyclopedic text that describes a disease of moderate interest. The two authors are highly credible authorities; however, the credibility of some of the contributors is less striking.
Features: The illustrations are adequate with average pedagogic value. Although some might think that it is impossible to overreference a book, this text disputes that belief. The unique features include a useful patient and health care provider guide to SLE.
Assessment: There is no question that SLE is an interesting disease, but does it merit a text of this magnitude? Moreover, because there have been no dramatic leaps in understanding of its pathogenesis, and the clinical course has not drastically changed, the need for an expanded new edition is not compelling. In a general sense, this edition misses a golden opportunity to present new or provocative concepts of SLE causation, but instead it dwells on overworked variations of immune complex etiology and long existing animal models, neither of which will provide significant clarity of insight into the disease. There has been no attempt to cull the wheat from the chaff. The result is an encyclopedic body of citations, apparently encompassing all SLE writing, past or present, within this galaxy. This book represents a well-meaning attempt to provide a central source of the body pertinent to SLE. The senior author is an excellent writer; he should strongly consider revamping the next edition to reflect his vast experience and delete the bells and whistles.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780683086652
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 11/18/1996
  • Edition description: REV
  • Edition number: 5
  • Pages: 1289

Table of Contents

Contributing Authors
Preface
1 Historical Background of Discoid and Systemic Lupus Erythematosus 3
2 Definition, Classification, Activity, and Damage Indices 19
3 The Role of Environment in Systemic Lupus Erythematosus and Associated Disorders 33
4 The Epidemiology of Systemic Lupus Erythematosus 65
5 An Overview of the Pathogenesis of Systemic Lupus Erythematosus 87
6 The Genetics of Human Lupus 97
7 The Genetics of Murine Systemic Lupus Erythematosus 121
8 Apoptosis 145
9 T Lymphocytes, Natural Killer Cells, and Immune Regulation 157
10 Cytokines in the Pathogenesis of Systemic Lupus Erythematosus 187
11 B-Cell Abnormalities in Systemic Lupus Erythematosus 205
12 Abnormalities in Immune Complex Clearance and Fc[gamma] Receptor Function 219
13 Complement and Systemic Lupus Erythematosus 243
14 Mechanisms of Acute Inflammation and Vascular Injury in Systemic Lupus Erythematosus 261
15 Idiotypes and Idiotype Networks 281
16 The Importance of Sex Hormones in Systemic Lupus Erythematosus 307
17 Neuroendocrine Immune Interactions: Principles and Relevance to Systemic Lupus Erythematosus 319
18 Animal Models of Systemic Lupus Erythematosus 339
19 The Structure and Derivation of Antibodies and Autoantibodies 391
20 Antinuclear Antibodies: An Overview 415
21 Antibodies to DNA 425
22 Antibodies to Histone and the Role of the Nucleosome 447
23 Antibodies to Ro/SSA and La/SSB 467
24 Anti-snRNP Antibodies 481
25 The Lupus Anticoagulant and Antiphospholipid Antibodies 495
26 Autoantibodies, Autoantigens, and Nervous System 509
27 Other Serologic Abnormalities in Systemic Lupus Erythematosus 523
28 Pathomechanisms of Cutaneous Lupus Erythematosus 549
29 Cutaneous Manifestations of Lupus Erythematosus 573
30 The Clinical Presentation of Systemic Lupus Erythematosus 621
31 The Musculoskeletal System 629
32 Cardiovascular Manifestations of Systemic Lupus Erythematosus 645
33 Pulmonary Manifestations of Systemic Lupus Erythematosus 663
34 Selected Cutaneovascular Manifestations of Systemic Lupus Erythematosus 685
35 Systemic Lupus Erythematosus and the Nervous System 693
36 Psychopathology in the Patient With Lupus 739
37 Head and Neck Findings in Systemic Lupus Erythematosus: Sjogren's Syndrome and the Eye, Ear, and Larynx 775
38 Hematologic and Lymphoid Abnormalities in Systemic Lupus Erythematosus 793
39 The Use of Exogenous Estrogens, Endocrine System, and Urogenital Tract 821
40 Gastrointestinal and Hepatic Manifestations 843
41 Systemic Lupus Erythematosus in Childhood and Adolescence 863
42 Drug-Induced Lupus 885
43 Infections in Systemic Lupus Erythematosus 917
44 Serum and Plasma Protein Abnormalities and Other Clinical Laboratory Determinations in Systemic Lupus Erythematosus 927
45 Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus 939
46 Differential Diagnosis and Disease Associations 959
47 The Mother in Systemic Lupus Erythematosus 985
48 The Fetus in Systemic Lupus Erythematosus 1023
49 The Neonatal Lupus Syndrome 1041
50 Lupus Nephritis: Pathology, Pathogenesis, Clinical Correlations, and Prognosis 1061
51 Clinical and Laboratory Features of Lupus Nephritis 1077
52 Clinical and Management Aspects of the Antiphospholipid Antibody Syndrome 1093
53 Principles of Therapy and Local Measures 1131
54 Salicylate and Nonsteroidal Therapy 1141
55 Antimalarial Therapies 1149
56 Systemic Glucocorticoid Therapy in Systemic Lupus Erythematosus 1173
57 Immunosuppressive Drug Therapy 1195
58 Nonpharmacologic Therapeutic Modalities 1219
59 Occasional, Innovative, and Experimental Therapies 1229
60 Adjunctive Measures and Issues: Allergies, Antibiotics, Vaccines, Osteoporosis, and Disability 1243
61 Prognosis, Mortality, and Morbidity in Systemic Lupus Erythematosus 1255
62 Experimental Therapies in Systemic Lupus Erythematosus 1275
App. I Patient's Guide to Lupus Erythematosus 1287
App. II Lupus Resources for Patients, Physicians, and Health Professionals 1299
Subject Index 1309
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