Dagwood Bumstead (Arthur Lake) is invited by his boss Mr. Dithers (Jonathan Hale) to accompany Dithers on an ocean cruise to South America. Dagwood's whole family comes along, including wife Blondie (Penny Singleton), son Baby Dumpling (Larry Simms) and Daisy the dog and her pups. Just before sailing, Dagwood is compelled to stay behind and watch over Dithers' business. Determined to rejoin his family, Dagwood dresses up in drag and joins the ship's all-girl orchestra. The ruse continues all the way to South America, where Dagwood must fume while Blondie is serenaded by dashing Tito Guizar. Blondie Goes Latin is the eighth in the Columbia series based on the comic strip by Chic Young.