A group of adventurous young friends on a trip to the Caribbean decide to explore a secluded island, where they unleash a highly contagious, flesh-eating virus after swimming in contaminated water, and exploring a research facility that houses a terrifying secret. Somewhere on an uncharted island deep in the Caribbean, the doctors at a secluded research lab have managed to quarantine Porter (Sean Astin), the first person to be infected by an aggressive flesh-eating virus. Meanwhile, not too far away, Marcus (Mitch Ryan) is preparing to get married when his brother Josh (Brando Eaton), Josh's girlfriend Penny (Jillian Murray), and their best friend Dobbs (Ryan Donowho) lure him onto a luxury yacht to celebrate his last night of freedom. Upon arriving at a picturesque island that isn't on the maps, Josh and Penny stay on the beach to do a little snorkeling while Marcus and Dobbs set up the campsite. Returning to the tent in a panic after spotting scores of dead fish in the water, Penny breaks out in a rash that Josh credits to some bad local ganja. Later, when Josh also shows signs of infection, Marcus and Dobbs venture out for help and break into the darkened research facility, which appears to have been the scene of a bloody struggle. Their worst fears are realized when they discover that they have stumbled upon the site of a deadly outbreak, and that the egomaniacal doctor (Currie Graham) in charge is determined to take credit for curing the disease -- even if it means that no one gets off the island alive.