One of the more difficult high school students in cinematic history moves on to college in this sexy thriller. Debbie Strand (Jodi Lyn O'Keefe, in the role Rose McGowan played in the first film) was sentenced to a mental institution for the criminally insane after her previous murder spree, but she manages to escape, and while making her getaway by hitchhiking, she's picked up by Sydney Hollings (Christiana Frank), a student on her way to start classes at an upscale college nearby. Debbie murders Sydney and assumes her identity in hopes of avoiding the police, but Debbie's obsession with older men starts causing problems again when she becomes interested in Sam Decker (Jsu Garcia), one of her professors. Debbie soon learns that she has a rival for Sam's affections in Carla (Katherine Kendall), Sam's girlfriend, and this proves to be bad for the long-term health of all parties concerned. Debbie also finds she doesn't get along especially well with her new roommate, Laney (Jeanette Brox). Devil in the Flesh 2 was also screened under the title Teacher's Pet.