Margaret O'Brien, MGM's newest child sensation, was given her first starring vehicle with Lost Angel. O'Brien plays Alpha, who has been groomed to be a genius by a trio of well-meaning but misguided professors (Philip Merivale, Henry O'Neill and Donald Meek). Taking pity on the reluctant prodigy, police reporter Mike Regan (James Craig) takes it upon himself to "deprogram" Alpha and transform her into a normal, healthy child. In an effort to inflate this B picture into "A" proportions by increasing the running time, the scriptwriters contrive a silly subplot involving a gang of Runyonesque gangsters (headed by the ineluctable Keenan Wynn). Margaret O'Brien's appeal may be elusive to modern viewers, but she was a proven audience favorite back in 1944.