In this sequel to My Girl, Vada Sultenfuss (Anna Chlumsky) is now thirteen and at the crossroads of adolescence, beginning to question her past. Her father Harry (Dan Aykroyd) is now married to Shelly (Jamie Lee Curtis) and preoccupied with an expectant child. Vada feels left out and decides to write about her mother -- whom she knows nothing about -- for a school project. Vada wants to travel to Los Angeles during spring break to find out more about her mother by interviewing old friends and acquaintances. Harry is reluctant to let her go but finally agrees when he arranges for her to stay with her Uncle Phil (Richard Masur), who lives in L.A. with his girlfriend Rose (Christine Ebersole) and Rose's son Nick (Austin O'Brien), who happens to be the same age as Vada. Together Vada and Nick travel all over Los Angeles, uncovering revelations about Vada's mother and her past.