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  • Alternative view 1 of Splice
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2.2 4
Director: Vincenzo Natali

Cast: Adrien Brody, Sarah Polley, Delphine Chanéac


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Celebrated genetic engineers Clive (Adrien Brody) and Elsa (Sarah Polley) conduct a clandestine experiment to create an animal/human hybrid that could revolutionize modern medicine -- if it doesn't destroy humanity first. On the heels of engineering an entirely new species of animal, Clive and Elsa become the


Celebrated genetic engineers Clive (Adrien Brody) and Elsa (Sarah Polley) conduct a clandestine experiment to create an animal/human hybrid that could revolutionize modern medicine -- if it doesn't destroy humanity first. On the heels of engineering an entirely new species of animal, Clive and Elsa become the toast of the scientific community. Their experiment begins to spiral out of control, however, when the superstar scientists introduce human DNA into the equation. When Dren is born, Clive and Elsa welcome her into the world as the next leap in human evolution. Now, the faster Dren evolves, the more her creators start to realize they may have made a catastrophic mistake.

Editorial Reviews

All Movie Guide - Jeremy Wheeler
It seems fitting that just a few weeks after it was disclosed that humankind has successfully synthesized DNA, a nightmare version of this scientific breakthrough is unleashed on audiences in Vincenzo Natali's Splice. Equally thought-provoking and horrific in its imagery and the ripped-from-the-headlines subject matter, the picture is smart sci-fi that's not afraid to flirt with taboos while still existing enough on a B-movie playing field to satisfy the genre crowd. There's no doubt that some will dismiss it as another Species-style sci-fi B-movie, yet those who seek it out will find that there's more to this monster yarn than just the sex horror parallels. The tale is told through the eyes of Clive (Adrien Brody) and Elsa (Sarah Polley), two genetic engineers whose work is unparalleled in their field. After successfully making a new slug-like organism, the couple secretly defies the orders of their superiors in order to take genetic modification to the next level -- by making a hybrid human/animal synthetic being. The result of their haphazard experiment is Dren, a female humanoid whose staggeringly fast growth rate puts the scientists in the curious position of having to nurture this mutation as if it were their own child. Neither is prepared, however, for what happens when this innocent creature matures and lays waste to what they thought were their moral boundaries. Just as executive producer Guillermo del Toro finds exquisiteness in even the darkest of places, so does Natali present his all-too-real genetic creation as a radiant beauty whose vulnerability tests the sympathies of its audience just as much as its lead characters. The director, who hit the scene in 1997 with the low-budget shocker Cube, proves to be quite a visual virtuoso with this production. His adept usage of photorealistic effects sells Dren in such a way that many will forget just how much artistry was needed to bring her to life. The filmmaker is also given points for not shying away from some of the more illicit imagery, which the picture delivers with gusto. The two leads do a fine job with the material. The characters are fleshed out just enough for genre standards, but become more interesting as the film goes on, with each one shifting allegiance to the grave mistake they've unleashed on the world. One plot thread dealing with Elsa's backstory could have very well been larger in a different cut (the version shown at Sundance featured a longer running time), but in its own way, it's refreshing not to have it interfere with the final product. Special nods go out to Delphine Chanéac for her portrayal of Dren, whose arresting performance gives a unique spin on the Frankenstein mythos. Splice doesn't change the face of horror, nor does it usher in a new technology unknown to viewers, yet it is definitely a picture that's hard to forget. And despite some of its brainy underlying themes, it knows what gears it needs to hit to leave a monster-movie fan thoroughly weirded out and entertained.

Product Details

Release Date:
Original Release:
Warner Home Video

Cast & Crew

Performance Credits
Adrien Brody Clive
Sarah Polley Elsa
Delphine Chanéac Dren
Brandon McGibbon Gavin Nicoli
Simona Maicanescu Joan Chorot
David Hewlett William Barlow
Abigail Chu Child Dren

Technical Credits
Vincenzo Natali Director,Original Story,Screenwriter
Jean-Pierre Arquie Musical Direction/Supervision
Cyrille Aufort Score Composer
Bernard Bats Sound Mixer
Howard Berger Makeup Special Effects
Antoinette Terry Bryant Original Story,Screenwriter
John Buchan Casting
William Cheng Set Decoration/Design
Todd Cherniawsky Production Designer
Yves Chevalier Executive Producer
Angelo Colavecchia Camera Operator
BUF Compagnie Animator
Michele Conroy Editor
Joshu de Cartier Art Director
Constance Demontoy Casting
Sidonie Dumas Executive Producer
Amy Fritz Musical Direction/Supervision
Mac Guff Animator
Guillermo del Toro Executive Producer
Steven Hoban Producer
Alex Kavanagh Costumes/Costume Designer
Jason Knight Casting
Gordon Lebredt Set Decoration/Design
Brandon McGibbon Makeup Special Effects
Susan Montford Executive Producer
Don Murphy Executive Producer
Tetsuo Nagata Cinematographer
Gregory Nicotero Makeup Special Effects
Dan Norton Set Decoration/Design
John Papsidera Casting
C.O.R.E. Digital Pictures Animator
Joel Rangon Sound Mixer
Christophe Riandee Executive Producer
Marie Sabbah Musical Direction/Supervision
Andrew Shea Asst. Director
Joel Silver Executive Producer
Doug Taylor Screenwriter

Scene Index

A Director's Playground: Vincenzo Natali on the Set of Splice - Zoom in on the Innovative Filmmaker of the Global Cult Sensation Cube As He and His Creative Team Explore New Moviemaking Territory


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Splice 2.3 out of 5 based on 0 ratings. 4 reviews.
redstar2111379 More than 1 year ago
How do I even begin to review this particular film without entirely tearing it to pieces? The answer to that question is that I can't ... I definitely agree with Ruebels's review! And thank goodness that someone out there feels just as strong about this as I do! This falls into the category of stupid nonsensical crap that I'll seriously never watch again!
Anonymous More than 1 year ago
bridget3420 More than 1 year ago
Splice was an intense movie. I loved the plot and the acting was great. It's safe to say that there will be a second one.
Ruebels More than 1 year ago
At the risk of spoiling this ridiculas garbage, the "love" scene between Adrian Broody and Dren is the dumbest scene ever put to film.