In an apocalyptic future where the human race is poised on the brink of extinction and science has created the ultimate abomination of nature, a lone hunter gatherer realizes the essence of his being while fighting to survive. The year is 2015: the world's petroleum reserves have been depleted due to the oil wars, and the planet has fallen into a hopeless cycle of death and destruction. In an effort to remove the less desirable components of the human population, a powerful organization known only as The Corporation set into motion a heinous depopulation program. But The Corporation didn't expect their scientists to revolt, and in a desperate attempt to save the human race the disgruntled intellects created a drug that reverts normal humans into primitive, instinct-driven beasts known as Biosyns. Biosyns are virtually blind, relying almost entirely on scent and sound to stalk their prey. Max is a young man who lives by himself in the wilderness. Most of his days are spent eliminating as many Biosyns as possible, but lately he's been noticing something strange among the creature's ranks; not only are they beginning to communicate, but they're starting to travel in groups and their vision seems to be returning as well. The Corporations views Max's existence as a threat, and no they've dispatched a squad of genetically engineered soldiers known as Trackers to dispatch with him. But as the chief tracker watches Max battle a raging horde of Biosynths, he begins to reevaluate his original mission. Perhaps if Max and the Tracker can travel far enough south they will be able to find a place of refuge. According to travelers Zac and Rachel, there's s powerful resistance movement down south. Now, as this unlikely group struggles to find a way out of the wasteland, they stumble right into the middle of a violent war between the raging Biosyns and the Corporation's increasingly strained army.