Dynamic-Clamp: From Principles to Applications / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
Used and New from Other Sellers
Used and New from Other Sellers
from $151.99
Usually ships in 1-2 business days
(Save 47%)
Other sellers (Hardcover)
  • All (11) from $151.99   
  • New (7) from $183.41   
  • Used (4) from $151.99   


Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called "conductance injection") allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer. The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic-Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons. This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.

Read More Show Less

Product Details

  • ISBN-13: 9780387892788
  • Publisher: Springer New York
  • Publication date: 3/26/2009
  • Series: Springer Series in Computational Neuroscience, #1
  • Edition description: 2009
  • Edition number: 1
  • Pages: 429
  • Product dimensions: 9.21 (w) x 6.14 (h) x 1.00 (d)

Meet the Author

Dr. Alain Destexhe and Dr.Thierry Bal, are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the research unit (Unité de Neurosciences Intégratives et Computationnelles, UNIC). Gif-sur-Yvette is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Bal and Destexhe. Each editor holds Ph.D.s in both biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.

Read More Show Less

Table of Contents

Chapter 1: Associating living cells and computational models: from basics to present applications of the dynamic-clamp.Zuzanna Piwkowska, Alain Destexhe and Thierry Bal

Chapter 2: Dendritic dynamic clamp – a tool to study single neuron computation.Stephen R. Williams

Chapter 3: Synaptic conductances and spike generation in cortical cells.Hugh P.C. Robinson

Chapter 4: Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp.Frances Chance and Larry F. Abbott

Chapter 5: Impact of background synaptic activity on neuronal response properties revealed by stepwise replication of in vivo-like conditions in vitro.Steven A. Prescott and Yves De Koninck

Chapter 6: Testing methods for synaptic conductance analysis using controlled conductance injection with dynamic clamp.Zuzanna Piwkowska, Martin Pospischil, Michelle Rudolph-Lilith, Thierry Bal and Alain Destexhe

Chapter 7: Functional roles of shunting inhibition and IBK in rat and cat cortex.Lyle J. Graham and Adrien Schramm

Chapter 8: Functions of the persistent Na+ current in cortical neurons revealed by dynamic clamp.Johan F. Storm, Koen.Vervaeke, H. Hu, Lyle.J. Graham

Chapter 9: Using "Hard" Real-Time Dynamic Clamp to Study Cellular and Network Mechanisms of Synchronization in the Hippocampal Formation.John A. White, Fernando R. Fernandez, Michael N. Economo, and Tilman J. Kispersky

Chapter 10: Unraveling the dynamics of deep cerebellar nucleus neurons with the application of artificial conductances.Dieter Jaeger and Risa Lin

Chapter 11: Intrinsic and Network Contributions to Reverberatory Activity: Reactive Clamp and Modeling Studies.Jean-Marc Fellous, Terrence J. Sejnowski and Zaneta Navratilova

Chapter 12: Dynamic-clamp constructed hybrid circuits for the study of synchronization phenomena in networks of bursting neurons.Carmen C Canavier, Fred H Sielin and Astrid A Prinz

Chapter 13: Using the dynamic clamp to explore the relationship between intrinsic activity and network dynamics. Anne-Elise Tobin, Rachel G. Grashow, Lamont S. Tang, Stefan R. Pulver, and Eve Marder

Chapter 14: Re-creating in vivo-like activity and investigating the signal transfer capabilities of neurons: dynamic-clamp applications using Real-time NEURON.Gerard Sadoc, Gwendal Le Masson, Bruno Foutry, Yann Le Franc, Zuzanna Piwkowska, Alain Destexhe and Thierry Bal

Chapter 15: Using the dynamic clamp to dissect the properties and mechanisms of intrinsic thalamic oscillations.Stuart W. Hughes, Magor Lorincz, David W. Cope and Vincenzo Crunelli.

Chapter 16: Dynamic clamp with high resistance electrodes using Active Electrode Compensation in vitro and in vivo.Romain Brette, Zuzanna Piwkowska, Cyril Monier, José Francisco Gómez González, Yves Frégnac, Thierry Bal and Alain Destexhe

Chapter 17: Key Factors for Improving Dynamic Clamp Performance.Robert Butera and Risa Lin

Chapter 18: Development of a genetically engineered cardiac pacemaker: insights from dynamic action potential clamp experiments. Arie O. Verkerk, Jan G. Zegers, Antoni C. G. van Ginneken, and Ronald Wilders

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)