Dynamic Combinatorial Chemistry : In Drug Discovery, Bioorganic Chemistry, and Materials Science / Edition 1

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In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and molecular recognition in bioorganic chemistry and materials science.

Chapters cover:

Basic theory

Approaches to binding in proteins and nucleic acids

Molecular recognition


Catalyst discovery

Materials discovery

Analytical chemistry challenges

A comprehensive, singly-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.

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Editorial Reviews

From the Publisher

"I was pleased that both offerings are worthy of high commendation and that I did not have to make the difficult decision of recommending one book over the other; both are worthy candidates to be on library, faculty, and graduate student bookshelves." (Journal of the American Chemical Society, 15 April 2011)

"The scientific quality of the book is high, and the book can be recommended to novices and experienced researchers that want to explore new terrain in organic synthesis." (ChemMedChem, 2010)“This is an excellent and highly recommended textbook.” (Angewandte Chemie International Edition, June 2010)

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Product Details

  • ISBN-13: 9780470096031
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/2/2009
  • Edition number: 1
  • Pages: 265
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.70 (d)

Meet the Author

Benjamin L. Miller is an Associate Professor of Dermatology, Biomedical Engineering, and Biochemistry and Biophysics at the University of Rochester. In addition to his academic credentials, Dr. Miller has industry consulting experience as the founder of Adarza BioSystems and Lighthouse Biosciences.

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Table of Contents

Preface vii

Contibutors ix

Chapter 1 Dynamic Combinatorial Chemistry: An Introduction Benjamin L. Miller 1

Chapter 2 Protein-Directed Dynamic Combinatorial Chemistry Michael F. Greaney Venugopal T. Bhat 43

Chapter 3 Nucleic Acid-Targeted Dynamic Combinatorial Chemistry Peter C. Gareiss Benjamin L. Miller 83

Chapter 4 Complex Self-Sorting Systems Soumyadip Ghosh Lyle Isaacs 118

Chapter 5 Chiral Selection in DCC Jennifer J. Becker Michel R. Gagn? 155

Chapter 6 Dynamic Combinatorial Resolution Marcus Angelin Rikard Larsson Pornrapee Vongvilai Morakot Sakulsombat Olof Ramstr?m 169

Chapter 7 Dynamic Combinatorial Chemistry and Mass Spectrometry: A Combined Strategy for High Performance Lead Discovery Sally-Ann Poulsen Hoan Vu 201

Chapter 8 Dynamic Combinatorial Methods in Materials Science Takeshi Maeda Hideyuki Otsuka Atsushi Takahara 229

Index 261

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