Dynamic Combinatorial Chemistry : In Drug Discovery, Bioorganic Chemistry, and Materials Science / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$75.68
Used and New from Other Sellers
Used and New from Other Sellers
from $75.67
Usually ships in 1-2 business days
(Save 21%)
Other sellers (Hardcover)
  • All (13) from $75.67   
  • New (10) from $75.67   
  • Used (3) from $75.67   

Overview

In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and molecular recognition in bioorganic chemistry and materials science.

Chapters cover:

Basic theory

Approaches to binding in proteins and nucleic acids

Molecular recognition

Self-sorting

Catalyst discovery

Materials discovery

Analytical chemistry challenges

A comprehensive, singly-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.

Read More Show Less

Editorial Reviews

From the Publisher

"I was pleased that both offerings are worthy of high commendation and that I did not have to make the difficult decision of recommending one book over the other; both are worthy candidates to be on library, faculty, and graduate student bookshelves." (Journal of the American Chemical Society, 15 April 2011)

"The scientific quality of the book is high, and the book can be recommended to novices and experienced researchers that want to explore new terrain in organic synthesis." (ChemMedChem, 2010)“This is an excellent and highly recommended textbook.” (Angewandte Chemie International Edition, June 2010)

Read More Show Less

Product Details

  • ISBN-13: 9780470096031
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/2/2009
  • Edition number: 1
  • Pages: 265
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.70 (d)

Meet the Author

Benjamin L. Miller is an Associate Professor of Dermatology, Biomedical Engineering, and Biochemistry and Biophysics at the University of Rochester. In addition to his academic credentials, Dr. Miller has industry consulting experience as the founder of Adarza BioSystems and Lighthouse Biosciences.

Read More Show Less

Table of Contents

Preface vii

Contibutors ix

Chapter 1 Dynamic Combinatorial Chemistry: An Introduction Benjamin L. Miller 1

Chapter 2 Protein-Directed Dynamic Combinatorial Chemistry Michael F. Greaney Venugopal T. Bhat 43

Chapter 3 Nucleic Acid-Targeted Dynamic Combinatorial Chemistry Peter C. Gareiss Benjamin L. Miller 83

Chapter 4 Complex Self-Sorting Systems Soumyadip Ghosh Lyle Isaacs 118

Chapter 5 Chiral Selection in DCC Jennifer J. Becker Michel R. Gagn? 155

Chapter 6 Dynamic Combinatorial Resolution Marcus Angelin Rikard Larsson Pornrapee Vongvilai Morakot Sakulsombat Olof Ramstr?m 169

Chapter 7 Dynamic Combinatorial Chemistry and Mass Spectrometry: A Combined Strategy for High Performance Lead Discovery Sally-Ann Poulsen Hoan Vu 201

Chapter 8 Dynamic Combinatorial Methods in Materials Science Takeshi Maeda Hideyuki Otsuka Atsushi Takahara 229

Index 261

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)