Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology / Edition 1

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Dynamic contrast-enhanced MRI is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. The method assists clinical practitioners in the management of patients with solid tumors and is finding prominence in the assessment of tumor treatments, including anti-angiogenics, chemotherapy, and radiotherapy. Here, leading authorities discuss the principles of the methods, their practical implementation, and their application to specific tumor types. The text is an invaluable single-volume reference that covers all the latest developments in contrast-enhanced oncological MRI.

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Editorial Reviews

Doody's Review Service
Reviewer: Kavita Garg, M.D.(University of Colorado School of Medicine)
Description: This book is the first to cover a very important emerging area in oncology: angiogenesis and imaging with contrast enhanced MRI.
Purpose: It comprehensively covers application of dynamic contrast enhanced magnetic resonance imaging in oncology. The authors have met their objectives as effectively as possible, given the knowledge base in this new frontier in oncology.
Audience: This book is specially targeted for radiologists and oncologists including students, residents, and practitioners.
Features: The 16 chapters in this elegant book are well organized under four main headings. The first is on the principles of dynamic contrast enhanced MRI and the first chapter, an introduction to dynamic contrast enhanced MRI in oncology, is a must read. An excellent up-to-date review of pathophysiology of tumor angiogenesis and its correlation with contrast enhancement is next. The remaining five chapters in this first section are shorter and easy to follow. The next two chapters are related to imaging techniques, followed by six chapters in the clinical applications section and the final two chapters covering applications. Each chapter is well organized, starting with the outline of contents, and all the chapters are well referenced. Each chapter is also well illustrated with figures and tables. The time curves and schematic representations are especially relevant given the focus of this book. Some of the images are, however, somewhat noisy, such as the sagittal images of the cervix on page 177. The figure legends, especially for MR images, are somewhat long and somewhat confusing. Some of the MR images do not have any arrows or other identification tools that would be helpful in delineating the area of interest.
Assessment: This book is the first of its kind to comprehensively cover application of dynamic contrast enhanced magnetic resonance imaging in oncology. It will be of great interest to radiologists, oncologists, and scientists involved in more basic research. It is an excellent, comprehensive book on the subject and will be a welcome addition to all radiology and oncology departmental libraries.
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Product Details

  • ISBN-13: 9783642076077
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 1/27/2011
  • Series: Medical Radiology / Diagnostic Imaging Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2005
  • Edition number: 1
  • Pages: 311
  • Product dimensions: 8.20 (w) x 10.70 (h) x 0.80 (d)

Meet the Author

Alan Jackson, Professor of Neuroradiology at the University of Manchester, UK.

David Buckley, Lecturer in Magnetic Resonance Imaging at the University of Manchester, UK. Previous positions at the Universities of Florida, USA and Hull, UK.

Geoff Parker, Lecturer in Imaging Science at the University of Manchester, UK. Previous positions at the Institute of Neurology, London, UK and the Institute of Cancer Research, London, UK.

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Table of Contents

An Overview of Contrast-Enhanced MRI in Oncology (I.S. Gribbestad); Contrast Agents for Magnetic Resonance Imaging (T.P.L. Roberts/M. Noseworthy); The Role of Blood Pool Contrast Agents in the Study of Tumor Pathophysiology (R.C. Brasch); Dynamic Susceptibility Contrast-Enhanced MRI in Oncology (F. Calamante); Quantification of Contrast-Enhancement in Dynamic Studies (G.J.M. Parker/D. Buckley); Pharmacokinetic Modelling of Contrast Kinetics in Dynamic MR Studies (G. J.M. Parker/D. Buckley); IMAGING TECHNIQUES: Imaging Techniques for Dynamic Contrast-Enhanced Imaging (C.T.W. Moonen); Consensus Recommendations for Imaging in Angiogenesis (J. Evelhoch); CLINICAL APPLICATIONS: Dynamic Magnetic Resonance Imaging in Cerebral Malignancy (X.P. Zhu/K. Li); Dynamic Magnetic Resonance Imaging in Breast Tumours (M. Knopp); Dynamic Contrast Imaging in Cervical Carcinoma (N. Mayr et al.); Dynamic Contrast-Enhanced Imaging in the Prostate (A. Padhani); Contrast-Enhanced MR Imaging in Musculoskeletal Tumors (J.S. Taylor et al.); Contrast-Enhanced MR Imaging in the Liver (X.P. Zhu/ A. Jackson); APPLICATIONS: The Use of Dynamic Contrast-Enhanced MRI Multicentre Trials (M. Leach); Applications of Dynamic Magnet Resonance in Drug Development (G. Jayson/J. Waterton); Subject Index; List of Contributors.

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