Effects of Ionizing Radiation: Atomic Bomb Survivors and Their Children (1945-1995)

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In the decades since the atomic bombing of Hiroshima and Nagasaki, economic and political trends have opened avenues for radiation research while breakthroughs in molecular biology have shed light on radiation's effect on the human body. This volume comprehensively reviews what is now known about human exposure to ionizing radiation, with emphasis on unifying the scientific disciplines that inform this topic. Today's most widely recognized ...
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Overview

In the decades since the atomic bombing of Hiroshima and Nagasaki, economic and political trends have opened avenues for radiation research while breakthroughs in molecular biology have shed light on radiation's effect on the human body. This volume comprehensively reviews what is now known about human exposure to ionizing radiation, with emphasis on unifying the scientific disciplines that inform this topic. Today's most widely recognized experts in the field examine four broad areas:
  • Physics and dosimetry, including the various systems of A-bomb survivor dosimetry, the effect on survivors of subsequent medical radiation, and chromosome aberrations as biomarkers.
  • Cancer statistics and epidemiology, including a historical review of leukemia risk in A-bomb survivors, the incidence of solid cancer and resulting mortality, and the results of studies of workers exposed to low-level radiation.
  • Genetics, including the path from radiation exposure to cellular effects, carcinogenesis, and mutagenesis. Experts discuss the interaction between radiation and other cancer risk factors, review models of radiation-induced cancer, and report on other aspects of molecular biology.
  • Psychological effects of radiation catastrophes--as seen at Hiroshima and Nagasaki, Three Mile Island, and Chernobyl--and consequences of the Atomic Bomb Survivors Relief Law.
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Editorial Reviews

Booknews
What is known about human exposure to ionizing radiation is examined in 20 contributions arranged in sections on physics and dosimetry, cancer statistics and epidemiology, mutagenesis and carcinogenesis, and the psychosocial factors of radiation catastrophes. Among the specific topics: medical radiation exposures of atomic bomb survivors, a historical review of leukemia risks in survivors, studies of workers exposed to low levels of external radiation, studies on the genetic effects of the atomic bomb, and atomic bomb survivors relief law. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780309064026
  • Publisher: National Academies Press
  • Publication date: 6/29/1998
  • Edition description: New Edition
  • Pages: 400

Table of Contents

Preface
Pt. I Radiation Physics and Dosimetry
1 Development of A-Bomb Survivor Dosimetry 3
2 The Origin of DS86 31
3 Medical Radiation Exposures of Atomic Bomb Survivors 51
4 Biodosimetry of Atomic Bomb Survivors by Karyotyping, Chromosome Painting, and Electron Spin Resonance 73
Pt. II Cancer Statistics and Epidemiology
5 Statistical Aspects of RERF Cancer Epidemiology 91
6 A Historical Review of Leukemia Risks in Atomic Bomb Survivors 101
7 Tumor Registries and Cancer Incidence Studies 117
8 Solid Cancer Incidence and Mortality in the Life Span Study of Atomic Bomb Survivors 131
9 Studies of Workers Exposed to Low Levels of External Radiation 143
Pt. III Mutagenesis and Carcinogenesis
10 Studies on the Genetic Effects of the Atomic Bombs: Past, Present, and Future 159
11 Radiation, Signal Transduction, and Modulation of Intercellular Communication 177
12 Interaction Between Radiation Dose and Other Cancer Risk Factors 193
13 A Simplified Model of Radiation Carcinogenesis in the Atomic Bomb Survivors 213
14 Mechanistic Modeling of Radiation-Induced Cancer 221
15 The Distinction in Radiobiology Between Medical and Public Health Functions 237
16 Molecular Analyses of In Vivo hprt Mutations in Humans 253
17 Evolution of the Glycophorin A Assay for Measuring Biological Effects of Radiation on Humans 271
Pt. IV Psychosocial Factors
18 Psychological Effects of Radiation Catastrophes 283
19 Atomic Bomb Survivors Relief Law 295
Pt. V Future Research
20 The Ultimate Questions: Future Research at RERF 303
Bibliography 311
Contributors 356
Index 359
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