Efficacy of Myocardial Infarction Therapy: An Evaluation of Clinical Trials Evidence

Efficacy of Myocardial Infarction Therapy: An Evaluation of Clinical Trials Evidence

by Valentin Fuster, Ara S. Nash
     
 

In this unique reference, nearly 50 principal investigators of major clinical trials of myocardial infarction (MI) therapy explain how their work has contributed to the current standard of care.
Includes the work of researchers at an impressive range of distinguished institutions worldwide!
Providing the basis for treatment guidelines, Efficacy of

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Overview

In this unique reference, nearly 50 principal investigators of major clinical trials of myocardial infarction (MI) therapy explain how their work has contributed to the current standard of care.
Includes the work of researchers at an impressive range of distinguished institutions worldwide!
Providing the basis for treatment guidelines, Efficacy of Myocardial Infarction Therapy

  • examines clinical trials that have established the efficacy of particular therapies, including acute coronary reperfusion; the use of aspirin, beta blockers, and ACE inhibitors; and the reduction of blood cholesterol
  • reviews trials that have cast doubt on the efficacy of other therapies, including the early and late use of calcium channel blockers, and the routine use of heparin, nitroglycerin, and magnesium
  • deals with alternative overall strategies for myocardial infarction care, such as invasive versus conservative management and the interplay of thrombolysis and PTCA
  • and more!
    Including over 1400 references, tables, drawings, and photographs Efficacy of Myocardial Infarction Therapy benefits cardiologists, internists, family practitioners, fellows, residents, and graduate and medical school students in these disciplines.
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    Editorial Reviews

    Doody's Review Service
    Reviewer: John F. Moran, MD (Loyola University Stritch School of Medicine)
    Description: This text reviews all the treatments for acute myocardial infarction with proven efficacy, unproven efficacy, and alternative therapy approaches. There are good reviews of thrombolysis, angioplasty, aspirin usage, beta blockade, ACE inhibition, and cholesterol reduction.
    Purpose: The purpose is to detail evidence of proven therapies to help improve treatment for acute myocardial infarction.
    Audience: This text is directed to those physicians taking care of patients with acute myocardial infarctions. The contributors are often the same physician investigators involved in the trials they write about here.
    Features: The majority of the text is directed to treatment of proven efficacy: thrombolysis, coronary angioplasty, aspirin, beta blockade, ACE inhibition, and cholesterol reduction. There are smaller sections of the book devoted to relatively unproven therapy such as nitrates, Heparin anticoagulation, and magnesium. There is a good discussion of the trials comparing urgent invasive approach versus conservative therapy for acute myocardial infarction. The primary drawback is that this publication will necessarily leave out more recent trials of treatment for acute myocardial infarction. The importance of this text is in explaining the data needed to treat our patients more effectively. These treatments need to be used more often.
    Assessment: This is a good review of the arsenal of therapies for acute myocardial infarction and the evidence supporting their use. There are several publications on clinical trials available but they either give too brief a listing or take too broad a cardiologic approach. This book has the advantage of a pointed discussion of the trials in question and a review of their place in the spectrum of therapy written by the original investigators.
    Claude Lenfant
    From the Foreword: Cardiologists, and when necessary general physicians, have now an arsenal of weapons to combat myocardial infarction. This volume is a visit to that arsenal: to my knowledge, there is no other volume where one could find so readily accessible all the information concerning the many interventions that are available today. Clinical trials are described, explained and evaluated, thus giving the physician the ability to apply effectively the remarkable knowledge that is available. Much credit must be given to the editors and the many contributors for providing the medical community with such a lucid and helpful review.
    Acta Cardiologica
    ...a very comprehensive and lucid review of myocardial infarction trials and...highly recommended for all those caring for patients with myocardial infarction.
    John F. Moran
    This text reviews all the treatments for acute myocardial infarction with proven efficacy, unproven efficacy, and alternative therapy approaches. There are good reviews of thrombolysis, angioplasty, aspirin usage, beta blockade, ACE inhibition, and cholesterol reduction. The purpose is to detail evidence of proven therapies to help improve treatment for acute myocardial infarction. This text is directed to those physicians taking care of patients with acute myocardial infarctions. The contributors are often the same physician investigators involved in the trials they write about here. The majority of the text is directed to treatment of proven efficacy: thrombolysis, coronary angioplasty, aspirin, beta blockade, ACE inhibition, and cholesterol reduction. There are smaller sections of the book devoted to relatively unproven therapy such as nitrates, Heparin anticoagulation, and magnesium. There is a good discussion of the trials comparing urgent invasive approach versus conservative therapy for acute myocardial infarction. The primary drawback is that this publication will necessarily leave out more recent trials of treatment for acute myocardial infarction. The importance of this text is in explaining the data needed to treat our patients more effectively. These treatments need to be used more often. This is a good review of the arsenal of therapies for acute myocardial infarction and the evidence supporting their use. There are several publications on clinical trials available but they either give too brief a listing or take too broad a cardiologic approach. This book has the advantage of a pointed discussion of the trials in question and a review of their place in the spectrumof therapy written by the original investigators.
    Booknews
    Contributors review therapies with and without established efficacy, and explore alternative strategies in acute myocardial infarction. Part one examines the clinical trials that have established the efficacy of particular therapies: acute coronary reperfusion by either pharmacological or mechanical means, the use of aspirin, the early and late use of beta-blockers, the early and late use of ACE inhibitors, and the reduction of blood cholesterol. Part two reviews the trials that have cast doubt on the efficacy of others: early and late use of calcium channel blockers and the routine use of heparin, nitroglycerin, and magnesium. Finally, part three deals with alternative overall strategies: invasive versus conservative management and the interplay of thrombolysis and PTCA. Annotation c. by Book News, Inc., Portland, Or.

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    Product Details

    ISBN-13:
    9780824719326
    Publisher:
    Taylor & Francis
    Publication date:
    02/28/1999
    Edition description:
    New Edition
    Pages:
    520
    Product dimensions:
    6.00(w) x 9.00(h) x 1.25(d)

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