Elastic Filaments of the Cell by H.L. Granzier, Paperback | Barnes & Noble
Elastic Filaments of the Cell

Elastic Filaments of the Cell

by H.L. Granzier
     
 

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Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become

Overview

Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.

Editorial Reviews

Booknews
Contains proceedings of a June 1999 conference held at the University of Washington, focusing on progress made in understanding elastic protein filaments. Papers are in sections on elastic filaments of the cell, molecular mechanism of elasticity, titin-like proteins, and the functional role of elastic filaments. Specific topics include computer modeling of force-induced titin domain unfolding, the contribution of kettin to the elasticity of insect muscles, mechanical properties of titin isoforms, and titin-thin filament interaction and potential role in muscle function. Granzier is affiliated with Washington State University; Pollack with the University of Washington. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9781461369165
Publisher:
Springer US
Publication date:
12/31/2013
Series:
Advances in Experimental Medicine and Biology Series, #481
Edition description:
Softcover reprint of the original 1st ed. 2000
Pages:
425
Product dimensions:
7.01(w) x 10.00(h) x 0.04(d)

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