Elastomeric Proteins: Structures, Biomechanical Properties, and Biological Roles

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Elastic proteins occur in a wide range of biological systems where they have evolved to fulfill precise biological roles. The best known include proteins in vertebrate muscles and connective tissues, such as titin, elastin, fibrillin and spider silks. Interest in elastomeric proteins is currently high for several reasons. Firstly, they have biological and medical significance, particularly in human disease. Secondly, the unusual properties of proteins such as spider silks provide opportunities to develop novel materials. Thirdly, the development of scanning probe microscopy makes it possible to study structures and biomechanical properties of these proteins at the single molecule level.

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Product Details

  • ISBN-13: 9780521128483
  • Publisher: Cambridge University Press
  • Publication date: 2/4/2010
  • Pages: 416
  • Product dimensions: 6.00 (w) x 8.90 (h) x 1.00 (d)

Table of Contents

1 Functions of Elastomeric Proteins in Animals 1
2 Elastic Proteins: Biological Roles and Mechanical Properties 15
3 Elastin as a Self-Assembling Biomaterial 39
4 Ideal Protein Elasticity: The Elastin Models
5 Fibrillin: From Microfibril Assembly to Biomechanical Function 94
6 Spinning an Elastic Ribbon of Spider Silk 115
7 Sequences, Structures, and Properties of Spider Silks 136
8 The Nature of Some Spiders' Silks 152
9 Collagen: Hierarchical Structure and Viscoelastic Properties of Tendon 175
10 Collagens with Elastin- and Silk-like Domains 189
11 Conformational Compliance of Spectrins in Membrane Deformation, Morphogenesis, and Signalling 213
12 Giant Protein Titin: Structural and Functional Aspects 242
13 Structure and Function of Resilin 259
14 Gluten, the Elastomeric Protein of Wheat Seeds 279
15 Biological Liquid Crystal Elastomers 302
16 Restraining Cross-Links in Elastomeric Proteins 321
17 Comparative Structures and Properties of Elastic Proteins 338
18 Mechanical Applications of Elastomeric Proteins-A Biomimetic Approach 352
19 Biomimetics of Elastomeric Proteins in Medicine 366
Index 379
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