Electropharmacological Control of Cardiac Arrhythmias: To Delay Conduction or to Prolong Refractoriness?

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Mount Kisco, NY 1994 Hardcover Very Good Ex-Library Cond Book 8vo-over 7?"-9?" tall 746 pgs. Divided into the parts: electrophysiological considerations; mechanism of cardiac ... arrhythmias; pharmacological considerations; clinical considerations and therapeutic implications; controlling cardiac arrhythmias by prolonging repolarization; emerging class III compounds of potential clinical utilitynonpharmacological approaches to cardiac arrhythmias; and future perspectives. Binding slightly cocked (unsquare), and the hinges are starting to loosen a bit. Binding still intact. Usual library markings. Read more Show Less

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Editorial Reviews

Doody's Review Service
Reviewer: Robert J. Hariman, MD, FACC (Loyola University Stritch School of Medicine)
Description: This book covers various aspects of basic cardiac electrophysiology and clinical cardiac arrhythmias. The authors are world-renowned experts in their fields.
Purpose: The main purpose is to describe newer aspects of the control of cardiac arrhythmias. This complex and rapidly evolving area requires a constant update. The book intends to cover the pharmacological and nonpharmacological aspects of the treatment of cardiac arrhythmias. It also describes the basic electrophysiological considerations and basic mechanisms of arrhythmias. These are all worthy objectives that were elegantly met.
Audience: The appropriate audience would be basic scientists doing research in cardiac electrophysiology as well as clinicians treating patients with cardiac arrhythmias. Cardiologists and cardiac electrophysiologists would benefit having this book in their libraries.
Features: Its strongest feature is the excellent quality of the authors and contributors. Not only are they experts in their fields, but they also have done original research that support the data they are presenting. The presentation using current and pertinent references, tables, and illustrations makes this book extremely lucid.
Assessment: This is an excellent book on basic and clinical cardiac electrophysiology that provides update from basic mechanisms to diagnosis and treatment of cardiac arrhythmias. This book should be in the libraries of basic scientists and clinicians interested in cardiac arrhythmias.
Robert J. Hariman
This book covers various aspects of basic cardiac electrophysiology and clinical cardiac arrhythmias. The authors are world-renowned experts in their fields. The main purpose is to describe newer aspects of the control of cardiac arrhythmias. This complex and rapidly evolving area requires a constant update. The book intends to cover the pharmacological and nonpharmacological aspects of the treatment of cardiac arrhythmias. It also describes the basic electrophysiological considerations and basic mechanisms of arrhythmias. These are all worthy objectives that were elegantly met. The appropriate audience would be basic scientists doing research in cardiac electrophysiology as well as clinicians treating patients with cardiac arrhythmias. Cardiologists and cardiac electrophysiologists would benefit having this book in their libraries. Its strongest feature is the excellent quality of the authors and contributors. Not only are they experts in their fields, but they also have done original research that support the data they are presenting. The presentation using current and pertinent references, tables, and illustrations makes this book extremely lucid. This is an excellent book on basic and clinical cardiac electrophysiology that provides update from basic mechanisms to diagnosis and treatment of cardiac arrhythmias. This book should be in the libraries of basic scientists and clinicians interested in cardiac arrhythmias.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780879935665
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/1/1994
  • Edition number: 1
  • Pages: 746

Table of Contents

Dedication
Acknowledgments
Contributors
Preface
Guest Preface
Pt. 1 Electrophysiological Considerations
Ch. 1 The Ionic Basis of the Heartbeat and of Cardiac Arrhythmias 3
Ch. 2 Cardiac Excitability and Myocardial Conduction 21
Ch. 3 Action Potential Duration and Refractoriness 33
Ch. 4 Significance of Autonomically Regulated Chloride Channels for Antiarrhythmic Drug Action 47
Ch. 5 Rate Dependence of Cardiac Repolarization: Autonomic Modulation and Interference with Antiarrhythmic Drug Action 57
Pt. 2 Mechanism of Cardiac Arrhythmias
Ch. 6 General Concepts in the Mechanisms of Cardiac Arrhythmias 75
Ch. 7 Abnormalities in Depolarization-Mediating Arrhythmogenic Mechanisms: Focus on Anisotropy and Reentry 83
Ch. 8 Prolongation of Repolarization: Dispersion of Refractoriness or Afterdepolarizations 101
Ch. 9 Mechanisms of Atrial Arrhythmias 115
Ch. 10 Arrhythmia Mechanisms During Acute Ischemia 125
Ch. 11 Autonomic Control of Cardiac Arrhythmias 135
Ch. 12 The Role of Slow Conduction in the Genesis of Ventricular Tachycardia After Myocardial Infarction 151
Ch. 13 Mechanisms of Clinically Occurring Cardiac Arrhythmias 165
Ch. 14 Evolving Concepts in the Long QT Syndrome 183
Pt. 3 Pharmacological Considerations
Ch. 15 Comparative Mechanisms of Action of Antiarrhythmic Drugs 207
Ch. 16 Modes of Sodium Channel Blocking Action of Class I Drugs 225
Ch. 17 [beta]-Adrenoceptor Blockers as Antiarrhythmic Agents 237
Ch. 18 Molecular Mechanisms of Potassium Channel Block by Antiarrhythmic Drugs 247
Ch. 19 Calcium Channel Blockers 255
Ch. 20 Pharmacological Control of Experimental Atrial Arrhythmias: Significance of Prolonging Excitation Wavelength 265
Ch. 21 Mechanism of Action of Class III Versus Class I Antiarrhythmic Agents of Ventricular Tachycardia in the Infarcted Heart 279
Ch. 22 The Efficacy of Antiarrhythmic Drugs as Antifibrillatory Agents 291
Ch. 23 Experimental Determinations of Antiarrhythmic and Proarrhythmic Drug Action in Reentrant Ventricular Tachycardia 313
Ch. 24 Proarrhythmic Consequences of Pharmacologically-Induced Prolonged Repolarizations: Experimental Considerations 335
Pt. 4 Clinical Considerations and Therapeutic Implications
Ch. 25 Programmed Electrical Stimulation Versus Electrocardiographic Monitoring Guided Therapy for Ventricular Tachyarrhythmias 359
Ch. 26 Significance of the Cardiac Arrhythmia Suppression Trial CAST in the Survivors of Acute Myocardial Infarction 379
Ch. 27 Critical Analysis of Various Approaches to the Prevention of Sudden Death 387
Ch. 28 Impact of Calcium Channel Blockers on Mortality in Survivors of Acute Myocardial Infarction 399
Ch. 29 Antiarrhythmic Drug Therapy Based on Combination of Class III and Antiadrenergic Activity 413
Pt. 5 Controlling Cardiac Arrhythmias by Prolonging Repolarization
Ch. 30 Control of Cardiac Arrhythmias by Prolonging Repolarization: Historical Development of the Concept and Emerging Perspectives 427
Ch. 31 Circadian Rhythmicity of Heart Rate and Myocardial Repolarization: Implications for the Prevention of Ventricular Fibrillation 441
Ch. 32 Plasma Concentration Response Relations for Class III Antiarrhythmic Drugs: Are Pharmacokinetics Important? 457
Ch. 33 Sotalol and d-Sotalol: Electrophysiology, Pharmacology, and Role in Controlling Cardiac Arrhythmias 465
Ch. 34 Amiodarone: Pharmacological, Electrophysiological, and Clinical Profile of an Unusual Antiarrhythmic Compound 497
Pt. 6 Emerging Class III Compounds of Potential Clinical Utility
Ch. 35 Electrophysiological and Pharmacodynamic Profile of Sematilide HCL 525
Ch. 36 E-4031 535
Ch. 37 Evolving Experimental and Clinical Profile of Dofetilide 551
Ch. 38 Electropharmacological Profile and Antiarrhythmic Potential of Almokalant 569
Ch. 39 Electrophysiological and Pharmacodynamic Properties and Pharmacokinetics of MS-SS1, A New Class III Antiarrhythmic Compound 577
Ch. 40 Ibutilide 589
Ch. 41 Membrane Current Changes Responsible for the Class III Antiarrhythmic Properties of RP S8866 and its Active Enantiomer, RP 62719 597
Ch. 42 Ambasilide: A Novel Class III Antiarrhythmic Compound with a Differential Effect on Repolarization in Ventricular Muscle and Purkinje Fibers 611
Ch. 43 Electrophysiological and Hemodynamic Effects of WAY-123,398, a New Class III Antiarrhythmic Agent 629
Pt. 7 Nonpharmacological Approaches to Cardiac Arrhythmias
Ch. 44 Surgery for Cardiac Arrhythmias 645
Ch. 45 The Role of Catheter Ablation in the Management of Patients with Supraventricular and Ventricular Tachycardia 683
Ch. 46 Implantable Defibrillators: Implications for Antiarrhythmic Drug Therapy of Ventricular Arrhythmias 695
Pt. 8 Future Perspectives
Ch. 47 Whither Antiarrhythmic Drugs? 713
Index 733
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