Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications [NOOK Book]

Overview

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas

Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting ...

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Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications

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Overview

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas

Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research.

Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts:

  • Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware

  • Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces

  • Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers

  • Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra

  • Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery

Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.

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Editorial Reviews

From the Publisher
"Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, this volume will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry". (Anticancer Research, 1 August 2010)
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Product Details

  • ISBN-13: 9781118211557
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 9/26/2011
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 2
  • Pages: 847
  • File size: 26 MB
  • Note: This product may take a few minutes to download.

Meet the Author

RICHARD B. COLE, PHD, is a University Research Professor in The Department of Chemistry at The University of New Orleans. He has spent more than twenty-five years working in the field of mass spectrometry. His research interests include analytical/bio-organic chemistry as well as fundamentals and applications of mass spectrometry, with a focus on the development of novel analytical methods employing electrospray and MALDI.
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Table of Contents

Foreword: Desorption Ionization and Spray Ionization: Connections and Progress R. Graham Cooks vii

Foreword to the First Edition John B. Fenn xxi

Preface Richard B. Cole xxvii

Contributors xxix

Part I Fundamentals of ES

1 On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS) Paul Kebarle Udo H. Verkerk 3

2 Selectivity in Electrospray Ionization Mass Spectrometry Nadja B. Cech Christie G. Enke 49

3 Electrochemistry of the Electrospray Ion Source Gary J. Van Berkel Vilmos Kertesz 75

4 ESI Source Design Andries P. Bruins 123

Part II Fundamentals of MALDI

5 MALDI Ionization Mechanisms: and Overview Richard Knochenmuss 149

6 The Development of Matrix-Assisted Laser Desorption/Ionization Sources Peter B. O' Connor 185

7 A Comparison of MALDI Matrices Mahmud Hossain Patrick A. Limbach 215

8 MALDI Imaging Mass Spectrometry Alain Brunelle Olivier Lapréevote 245

Part III Es and MALDI Coupling to Mass Spectrometry Instrumentation

9 Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass Analyzers Mark E. Bier 265

10 Time-of-Flight Mass Spectrometry Robert J. Cotter 345

11 Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI Jeremy J. Wolff I. Jonathan Amster 365

12 Ion Mobility-Mass Spectrometry John A. McLean J. Albert Schultz Amina S. Woods 411

Part IV Practical Aspects of ES and MALDI

13 ESI, APCI, and MALDI a Comparison of the Central Analytical Figures of Merit: Sensitivity, Reproducibility, and Speed Thomas R. Covey Bradley B. Schneider Hassan Javaheri J.C. Yves LeBlanc Gordana Ivosev Jay J. Corr Peter Kovarik 443

14 Charge State Distributions in Electrospray and MALDI Yan Li Richard B. Cole 491

15 Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization Sonal Mathur Alexis Nazabal Renato Zenobi 535

16 Ion Activation Methods for Tandem Mass Spectrometry Kristina Håkansson John S. Klassen 571

17 Dissociation of Even-Electron Ions Carlos Afonso Richard B. Cole Jean-Claude Tabet 631

Part V Biological Applications of ES and MALDI

18 The Role of Mass Spectrometry for Peptide, Protein, and Proteome Characterization A. Jimmy Ytterberg Jason Dunsmore Shirley H. Lomeli Mario Thevis Yongming Xie Rachel R. Ogorzalek Loo Joseph A. Loo 685

19 Carbohydrate Analysis by ESI and MALDI David J. Harvey 723

20 Applications of ESI and MALDI to Lipid Analysis Xianlin Han 771

21 In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery Daniel B. Kassel 799

Index 825

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