Elements of Molecular Neurobiology / Edition 3

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Overview

This edition of the popular text incorporates recent advances in neurobiology enabled by modern molecular biology techniques. Understanding how the brain works from a molecular level allows research to better understand behaviours, cognition, and neuropathologies. Since the appearance six years ago of the second edition, much more has been learned about the molecular biology of development and its relations with early evolution. This "evodevo" (as it has come to be known) framework also has a great deal of bearing on our understanding of neuropathologies as dysfunction of early onset genes can cause neurodegeneration in later life. Advances in our understanding of the genomes and proteomes of a number of organisms also greatly influence our understanding of neurobiology.
* Well known and widely used as a text throughout the UK, good reviews from students and lecturers.
* Good complement to Fundementals of Psychopharmacology by Brian Leonard.
This book will be of particular interest to biomedical undergraduates undertaking a neuroscience unit, neuroscience postgraduates, physiologists, pharmacologists.
It is also a useful basic reference for university libraries.
Maurice Elphick, Queen Mary, University of London
"I do like this book and it is the recommended textbook for my course in Molecular Neuroscience. The major strength of the book is the overall simplicity of the format both in terms of layout and diagrams."

The book contains black-and-white illustrations.

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Editorial Reviews

From the Publisher
"…will prove very useful to every individual interested in molecular neurobiology research..." (Journal of Chemical Neuroanatomy, Vol.29, 2005)
Alexander Kolchinsky
This is an introductory course to molecular aspects of neurobiology written in the format of a textbook. It can also be used as a comprehensive introductory course for anyone who is interested in the field of neurobiology or as a reference book. The first six chapters outline the basics of molecular biology and genetics, brain anatomy, and membrane biophysics and could be skipped by a reader who did well in high school and first one or two years of college. The next 10 chapters describe molecular aspects of more specific neurobiological phenomena, such as ion channels and pumps, receptors, conduction neurotransmitters, and complicated processes of secretion and synaptic transmissions. The last four chapters discuss neurobiological issues at the next level of complexity: genetics of brain, mechanisms of memory, and molecular mechanisms of several major pathologies. The potential audience for the book is primarily college students; however, students at other levels, from high school up to graduate school, will appreciate it, as will advanced researchers. The book is richly illustrated by well designed and selected black-and-white schemes, drawings, and photographs. It has several appendixes, including useful basic data about neurons and lists of numerous confusing abbreviations used in neuroscience; a glossary; and a very convenient list of references that is subdivided according to chapters. The book would probably be somewhat more focused without descriptions of DNA structure and PCR that can be found elsewhere. It has its omissions; for instance, drug abuse might be discussed in the chapter on pathology. Nevertheless, it is very well written and organized and deserves a place amongthe best introductory courses in neurosciences.
From The Critics
Reviewer: Alexander Kolchinsky, PhD (University of Illinois at Chicago College of Medicine)
Description: This is an introductory course to molecular aspects of neurobiology written in the format of a textbook. It can also be used as a comprehensive introductory course for anyone who is interested in the field of neurobiology or as a reference book.
Purpose: The first six chapters outline the basics of molecular biology and genetics, brain anatomy, and membrane biophysics and could be skipped by a reader who did well in high school and first one or two years of college. The next 10 chapters describe molecular aspects of more specific neurobiological phenomena, such as ion channels and pumps, receptors, conduction neurotransmitters, and complicated processes of secretion and synaptic transmissions. The last four chapters discuss neurobiological issues at the next level of complexity: genetics of brain, mechanisms of memory, and molecular mechanisms of several major pathologies.
Audience: The potential audience for the book is primarily college students; however, students at other levels, from high school up to graduate school, will appreciate it, as will advanced researchers.
Features: The book is richly illustrated by well designed and selected black-and-white schemes, drawings, and photographs. It has several appendixes, including useful basic data about neurons and lists of numerous confusing abbreviations used in neuroscience; a glossary; and a very convenient list of references that is subdivided according to chapters.
Assessment: The book would probably be somewhat more focused without descriptions of DNA structure and PCR that can be found elsewhere. It has its omissions; for instance, drug abuse might be discussed in the chapter on pathology. Nevertheless, it is very well written and organized and deserves a place among the best introductory courses in neurosciences.
Booknews
A general reference and undergraduate textbook introducing the subject by reference to principles of molecular biology, biophysics, and neurobiology. Substantially updated from the 1989 edition, and places more emphasis on the genetic and molecular bases of neurological disease. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780471560388
  • Publisher: Wiley
  • Publication date: 11/1/2002
  • Edition description: REV
  • Edition number: 3
  • Pages: 630
  • Product dimensions: 7.44 (w) x 9.84 (h) x 1.36 (d)

Table of Contents

Preface.

Preface to the First Edition.

Preface to the Second Edition.

Introductory Orientation.

The Conformation of Informational Macromolecules.

Information Processing in Cells.

Molecular Evolution.

Manipulating Biomolecules.

Genomics.

Biomembranes.

G-protein-coupled Receptors.

Pumps.

Ligand-gated Ion Channels.

Voltage-gated Channels.

Resting Potentials and Cable Conduction.

Sensory Transduction.

The Action Potential.

The Neuron as a Secretory Cell.

Neurotransmitters and Neuromodulators.

The Postsynaptic Cell.

Developmental Genetics of the Brain.

Epigenetics of the Brain.

Memory.

Some Pathologies.

Appendix 1. Molecules and Consciousness.

Appendix 2. Units.

Appendix 3. Data.

Appendix 4. Genes.

Appendix 5. Physical Models of Ion Conduction and Gating.

Acronyms and Abbreviations.

Glossary.

Bibliography.

Index of Neurological Disease.

Index.

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