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This thoroughly revised and updated new edition of C.U.M. Smith's 1996 text gives an account of the molecular biology of the brain as it stands at the beginning of the twenty-first century. While retaining the overall structure of the second edition, this new edition incorporates: New material on genomics ion channels neural stem cells gap junctions channelopathies cannabinoids DNA-chips manipulation of K+-channels molecular bases of memory motor neuron disease (MND) Alzheimer's Disease (AD) Greater emphasis throughout on the molecular bases of disease The most up-to-date neuropharmacology Fifty new and/or revised illustrations Extensive bibliographies, including relevant web-sites
The book contains black-and-white illustrations.
Preface to the First Edition.
Preface to the Second Edition.
The Conformation of Informational Macromolecules.
Information Processing in Cells.
Ligand-gated Ion Channels.
Resting Potentials and Cable Conduction.
The Action Potential.
The Neuron as a Secretory Cell.
Neurotransmitters and Neuromodulators.
The Postsynaptic Cell.
Developmental Genetics of the Brain.
Epigenetics of the Brain.
Appendix 1. Molecules and Consciousness.
Appendix 2. Units.
Appendix 3. Data.
Appendix 4. Genes.
Appendix 5. Physical Models of Ion Conduction and Gating.
Acronyms and Abbreviations.
Index of Neurological Disease.