Elements of Molecular Neurobiology / Edition 2

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Overview

Extensively updated, revised and illustrated this unique introductory text presents a molecular account of the structure, function and development of the brain and nervous systems. This book describes the latest research in neurobiology made possible by modern molecular biology techniques. The author synthesizes this new knowledge and demonstrates how an understanding at the molecular level can contribute towards a theory of the brain in health and disease.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Alexander Kolchinsky, PhD (University of Illinois at Chicago College of Medicine)
Description: This is an introductory course to molecular aspects of neurobiology written in the format of a textbook. It can also be used as a comprehensive introductory course for anyone who is interested in the field of neurobiology or as a reference book.
Purpose: The first six chapters outline the basics of molecular biology and genetics, brain anatomy, and membrane biophysics and could be skipped by a reader who did well in high school and first one or two years of college. The next 10 chapters describe molecular aspects of more specific neurobiological phenomena, such as ion channels and pumps, receptors, conduction neurotransmitters, and complicated processes of secretion and synaptic transmissions. The last four chapters discuss neurobiological issues at the next level of complexity: genetics of brain, mechanisms of memory, and molecular mechanisms of several major pathologies.
Audience: The potential audience for the book is primarily college students; however, students at other levels, from high school up to graduate school, will appreciate it, as will advanced researchers.
Features: The book is richly illustrated by well designed and selected black-and-white schemes, drawings, and photographs. It has several appendixes, including useful basic data about neurons and lists of numerous confusing abbreviations used in neuroscience; a glossary; and a very convenient list of references that is subdivided according to chapters.
Assessment: The book would probably be somewhat more focused without descriptions of DNA structure and PCR that can be found elsewhere. It has its omissions; for instance, drug abuse might be discussed in the chapter on pathology. Nevertheless, it is very well written and organized and deserves a place among the best introductory courses in neurosciences.
Alexander Kolchinsky
This is an introductory course to molecular aspects of neurobiology written in the format of a textbook. It can also be used as a comprehensive introductory course for anyone who is interested in the field of neurobiology or as a reference book. The first six chapters outline the basics of molecular biology and genetics, brain anatomy, and membrane biophysics and could be skipped by a reader who did well in high school and first one or two years of college. The next 10 chapters describe molecular aspects of more specific neurobiological phenomena, such as ion channels and pumps, receptors, conduction neurotransmitters, and complicated processes of secretion and synaptic transmissions. The last four chapters discuss neurobiological issues at the next level of complexity: genetics of brain, mechanisms of memory, and molecular mechanisms of several major pathologies. The potential audience for the book is primarily college students; however, students at other levels, from high school up to graduate school, will appreciate it, as will advanced researchers. The book is richly illustrated by well designed and selected black-and-white schemes, drawings, and photographs. It has several appendixes, including useful basic data about neurons and lists of numerous confusing abbreviations used in neuroscience; a glossary; and a very convenient list of references that is subdivided according to chapters. The book would probably be somewhat more focused without descriptions of DNA structure and PCR that can be found elsewhere. It has its omissions; for instance, drug abuse might be discussed in the chapter on pathology. Nevertheless, it is very well written and organized and deserves a place amongthe best introductory courses in neurosciences.
Booknews
A general reference and undergraduate textbook introducing the subject by reference to principles of molecular biology, biophysics, and neurobiology. Substantially updated from the 1989 edition, and places more emphasis on the genetic and molecular bases of neurological disease. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
"...an excellent primer for the understanding of the fascinating aspects of brain structure, function and dysfunction at the molecular level..." (Jnl of Chemical Neuroanatomy, Vol.26, No.1, 2003)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780471960799
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 9/28/1996
  • Edition description: Older Edition
  • Edition number: 2
  • Pages: 534
  • Product dimensions: 7.50 (w) x 9.74 (h) x 1.17 (d)

Table of Contents

Preface
Preface to the First Edition
Preface to the Second Edition
1 Introductory Orientation
2 The Conformation of Informational Macromolecules
3 Information Processing in Cells
4 Molecular Evolution
5 Manipulating Biomolecules
6 Genomics
7 Biomembranes
8 G-protein-coupled Receptors
9 Pumps
10 Ligand-gated Ion Channels
11 Voltage-gated Channels
12 Resting Potentials and Cable Conduction
13 Sensory Transduction
14 The Action Potential
15 The Neuron as a Secretory Cell
16 Neurotransmitters and Neuromodulators
17 The Postsynaptic Cell
18 Developmental Genetics of the Brain
19 Epigenetics of the Brain
20 Memory
21 Some Pathologies
App. 1 Molecules and Consciousness
App. 2: Units
App. 3: Data
App. 4: Genes
App. 5 Physical Models of Ion Conduction and Gating
Acronyms and Abbreviations
Glossary
Bibliography
Index of Neurological Disease
Index
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