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Emerging Strategies in Neuroprotection

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Editorial Reviews

Reviews aspects of the search for drugs that will prevent the death of nerve cells after trauma to the brain, stroke, or such diseases as Alzheimer's and Parkinson's. Clinicians in the neurosciences may find helpful the descriptions of drugs already available; the material should also interest researchers and graduate students in neurological or medical sciences. The topics include tissue culture and animal models for research, transmitter receptors and blockers, and clinical trials and observations of various agents. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780817635442
  • Publisher: Birkhauser Verlag
  • Publication date: 8/28/1992
  • Series: Advances in Neuroprotection Series
  • Pages: 359
  • Product dimensions: 8.94 (w) x 7.96 (h) x 0.75 (d)

Table of Contents

1 Primary Cultures for Testing Neuroprotective Drugs 3
2 Modeling Neurodegeneration and Neuroprotection in Hippocampal Slices 24
3 Stroke Models for Preclinical Trials of Neuroprotective Agents 44
4 Animal Models of Ischemia 57
5 Head Trauma Model Systems 76
6 Excitotoxicity, Cerebral Ischemia, and Neuroprotection by Competitive NMDA Receptor Antagonists 93
7 Excitatory Amino Acids and Neuroprotection 106
8 Calcium Channel Blockers and Neuroprotection 129
9 Self-Defense of the Brain: Adenosinergic Strategies in Neurodegeneration 151
10 Gangliosides: New Generation of Neuroprotective Agents 187
11 Lazaroids: Novel Cerebroprotective Antioxidants 224
12 Membrane-Derived Lipid Second Messengers as Targets for Neuroprotection: Platelet-Activating Factor 238
13 Protection Against Oxidative Damage to CNS by [alpha]-Phenyl-tert-butyl Nitrone and Other Spin-Trapping Agents: A Novel Series of Nonlipid Free Radical Scavengers 252
14 Insulin, Hypoglycemia, and Ischemic Neuroprotection 273
15 Temperature Modulation of Neuronal Injury 289
16 Clinical Trial Issues in Stroke Therapy 309
17 Excitotoxicity and Neurodegenerative Disorders 326
Index 345
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