Encephalopathy and Nitrogen Metabolism in Liver Failure

Overview

Encephalopathy and Nitrogen Metabolism in Liver Failure contains research reports and state-of-the-art reviews that were presented at the 11th International Symposium on Hepatic Encephalopathy and Nitrogen Metabolism in relation to liver disease, that was held in Amsterdam, The Netherlands from 30 May to 1 June, 2002. Themes covered include the metabolism of ammonia and amino acids in relation to liver disease, the assessment of hepatic encephalopathy (HE), minimal HE, animal models of HE, neuropsychiatric ...

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Overview

Encephalopathy and Nitrogen Metabolism in Liver Failure contains research reports and state-of-the-art reviews that were presented at the 11th International Symposium on Hepatic Encephalopathy and Nitrogen Metabolism in relation to liver disease, that was held in Amsterdam, The Netherlands from 30 May to 1 June, 2002. Themes covered include the metabolism of ammonia and amino acids in relation to liver disease, the assessment of hepatic encephalopathy (HE), minimal HE, animal models of HE, neuropsychiatric dysfunction in patients with chronic liver disease, the pathogenesis of HE, the astrocyte in liver disease, acute liver failure and cerebral edema, treatment of HE and artificial liver support systems. This volume provides an indispensable source of important new research findings and ideas for clinicians and biomedical scientists working in the field of HE and nitrogen metabolism in relation to liver disease.

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Product Details

  • ISBN-13: 9781402011573
  • Publisher: Springer Netherlands
  • Publication date: 5/31/2003
  • Edition description: 2003
  • Edition number: 1
  • Pages: 437
  • Product dimensions: 7.10 (w) x 9.18 (h) x 0.94 (d)

Table of Contents

Preface
Acknowledgements
1 Novel aspects of nitrogen metabolism in liver disease
2 The interorgan exchange of amino acids and ammonia and the effect of plasmapheresis in acute liver failure 9
3 Metabolic consequences of an upper gastro-intestinal bleed in patients with cirrhosis 21
4 Citrin deficiency
5 Assessment of hepatic encephalopathy 43
6 Evaluation of mental state in a clinical trial of MARS for patients with acute hepatic encephalopathy: comparison of two scales 55
7 Relationship between minimal hepatic encephalopathy and extrapyramidal signs in cirrhotic patients 71
8 Evaluation of visual focus in cirrhotic patients 81
9 Detection of minimal hepatic encephalopathy: EEG spectral analysis vs. cognitive evoked potentials 87
10 Analysis of critical flicker frequency threshold in hepatic encephalopathy: dynamics and cortical activations 93
11 Cortical origin of mini-asterixis in hepatic encephalopathy 105
12 Imaging studies in hepatic encephalopathy
13 Subclinical and overt hepatic encephalopathy - detection and treatment control by proton magnetic resonance spectroscopy ([superscript 1]H-MRS) 125
14 Long-term observations on rats with thioacetamide-induced hepatic failure 137
15 Reversal of Fischer's ratio in an anesthetised porcine model of acute liver failure 145
16 Experience with neuropsychiatric complications of interferon-based therapy for chronic viral hepatitis 153
17 Cognitive effects of long-term interferon treatment for chronic viral hepatitis
18 Is fatigue of cholestasis mediated by altered central serotoninergic neurotransmission?
19 Reduced pallidal magnetisation transfer ratios are associated with fatigue in pre-cirrhotic patients with primary biliary cirrhosis
20 Pathogenesis of hepatic encephalopathy 177
21 Effect of blood plasma components from patients with hepatic encephalopathy on electrophysiological activity of primary frontal cortex networks in vitro 185
22 Hyperammonemia and liver failure alter signal transduction associated with glutamate receptors and modulation of guanylate cyclase by nitric oxide
23 Increased cerebral and peripheral vasodilation, and whole body nitric oxide production after insertion of a transjugular intrahepatic portal-systemic stent in patients with cirrhosis 209
24 Concomitant changes in melatonin metabolism and in hypothalamic histamine in rats with a portacaval anastomosis
25 Brain energy metabolism in acute liver failure: studies using NMR spectroscopy 225
26 Brain diffusion weighted MRI in cirrhosis
27 Role of manganese in hepatic encephalopathy 251
28 The mitochondrial permeability transition in ammonia neurotoxicity 267
29 Astroglial protein tyrosine nitration by ammonia
30 Use of NMR spectroscopy for the study of ammonia metabolism in astrocytes and neurons: role of glutamine synthesis in astrocytes 299
31 Brain uptake of ammonia in fulminant hepatic failure: the role of cerebral blood flow 315
32 Effect of erythropoietin on intracranial pressure and brain water in rats with hyperammonemia 325
33 Prevention of brain edema in acute liver failure by hypothermia: recent advances 333
34 Treatment of hepatic encephalopathy 343
35 Rifaximin reduces EEG relative beta power in patients with minimal hepatic encephalopathy: preliminary findings 361
36 Naloxone treatment of human hepatic encephalopathy 369
37 Liver support systems: issues and challenges 377
38 Clinical application of bioartificial liver support systems 389
39 Molecular Adsorbents Recirculating System (MARS) for acute decompensation of chronic liver disease: an early clinical experience 407
40 Hypothermia for the management of intracranial hypertension in acute liver failure 415
41 The potential of molecular biological techniques in research on hepatic encephalopathy 425
Index 435
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