Description: This book details the impact of environmental endocrine disruptors, exogenous chemicals that modulate endogenous hormonal axes, on pubertal development. With strong roots in both human and animal data, it outlines the many emerging connections linking environmental insults to altered sexual development.
Purpose: The editors set out to provide a comprehensive analysis of the basic science and clinical literature linking endocrine disruptors with alterations in pubertal development. The changes in sexual maturation observed in the clinic warrant a careful exploration of all contributors to these significant changes. Thankfully, the editors and authors have done a masterful job in assembling the relevant data linking chemical exposures to pubertal development.
Audience: Although written for an academic audience with an interest in the impact of endocrine disruptors on human health as well as animal development, interested students and clinicians will find the work accessible. Educated lay audiences with an interest in this emerging field of endocrinology should be able to navigate this book.
Features: The editors have employed an excellent group of authors to contribute diverse chapters exploring the various perspectives on endocrine disruption of pubertal development. Included are chapters describing the evidence linking chemical exposures to alterations in human development as well as basic science chapters that define what is known about chemical effects on animal sexual development. The book's translational focus includes specific chapters that discuss the mouse-to-human spectrum of effects. The final section explores the implications of environmental pollutants on pubertal development by specifically examining the observed changes in pubertal timing over the last several decades. Collectively, these studies provide a comprehensive analysis of endocrine disruption of puberty.
Assessment: Changes in pubertal timing over the last several decades raise important questions about the effects of environmental pollutants on human health. Anyone interested in understanding how pubertal development can be disturbed by endocrine disruptors will find this book both incredibly interesting and very useful.