Endocrine Disruptors: Effects on Male and Female Reproductive Systems / Edition 2

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There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of these endocrine disruptors, it is imperative to update our knowledge of these controversial chemicals.

Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition examines the reproductive and health hazards of endocrine-disrupting environmental chemicals from epidemiology to etiology, concluding with future directions. Divided into two sections, the first part of the book describes the effects of environmental toxicants on the female reproductive system, with an emphasis on the effects and mechanisms of their action on sex differentiation during development, fertility, and breast cancer. The second part addresses the effects of endocrine disruption on the male reproductive system, focusing on male fertility and the development of benign prostate hyperplasia (BPH) and prostate cancer.

Leading authorities contribute expert analyses and up-to-date information on a topic that has become a major concern among the scientific community and the general public. This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population.

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Editorial Reviews

Doody's Review Service
Reviewer: J. Thomas Pierce, MBBS PhD(Navy Environmental Health Center)
Description: This book on endocrine disruptors is divided into two sections. The first treats the effects of environmental toxicants on the female reproductive system, with special emphasis on effects and mechanisms. It contains chapters discussing both female endocrinology and carcinogenesis. The second section deals with the effects of endocrine disruption by environmental toxicants on the male reproductive systems, focusing on male fertility and development of benign prostate hyperplasia and prostate cancer.
Purpose: In the five years since the appearance of the first edition, numerous advances have emerged in both the basic science and the clinical issues pertinent to endocrine disruptors. The editor also notes concern among the scientific community, policy makers, and the general public regarding reproductive and health hazards of endocrine-disrupting environmental chemicals.
Audience: The editor provides clues that that the second edition will be useful to endocrine reproductive biologists and to associated clinical scientists. Actually, some of the more molecular and embryology oriented chapters are quite good, possibly attracting interest across an even broader range of individuals interested in reproductive biology. Furthermore, although the book is written at a high level, I believe it will be referenced by policy makers and the general public, who may sometimes have to rely upon basic and clinical scientists for further interpretation of key words.
Features: The editor argues that the second edition is a model source of recent, updated, vital and viable scientific information on endocrine disruption. Based upon the distinguished panel of authors, I tend to agree. In fairness, the book has been kept to a reasonable size, about 450 pages. Chapter references extend to 100-150 entries and are current and significant. I was pleased I was able to retrieve chemical names or pathologic terms using the index.
Assessment: Certainly, the press of new scientific articles since the book's original publication in 1999 demands a second edition. The editor indicates the book is a somewhat unique entity. There are probably more encyclopedic references on the results of endocrine disruption, but they do not do as much to explain the molecular mechanisms of these phenomena.
Examines the epidemiology and etiology of environmental toxicants, also known as hormone impostors, many of which act as reproductive toxicants that cause fertility problems. The 12 contributions address issues such as declining global fertility, rising incidences of breast and prostate cancer, and the wide variety of toxic affects that the synthetic chemicals exert on the gonads, fertility, and sexual and reproductive function. Individual topics include: how diethylstilbestrol and environmental estrogens influence the developing female reproductive system; dietary phytoestrogens; endocrine disrupters and male infertility; and the role of natural and man made estrogens in prostate development. Annotation c. by Book News, Inc., Portland, Or.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780849322815
  • Publisher: Taylor & Francis
  • Publication date: 11/24/2004
  • Edition description: REV
  • Edition number: 2
  • Pages: 464
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.20 (d)

Table of Contents

Section I Effect on the Female Reproductive System
Disruption of Nongenomic Steroid Actions on Gametes and Serotonergic Pathways Controlling Reproductive Neuroendocrine Function by Environmental Chemicals, Peter Thomas and Izhar A. Khan
Developmental and Reproductive Abnormalities Associated with Environmental Estrogens: Diethylstilbestrol (DES) as an Example, Retha R. Newbold and Wendy Jefferson
Ovotoxic Environmental Chemicals: Indirect Endocrine Disruptors, Patrick J. Devine and Patricia B. Hoyer
p,p'-DDE and HCB: Mechanisms of Toxicity to Fetal and Embryonic Mammalian Cells, Michael A. Edelbrock, Marta J. Fernstrom, and Kandance J. Williams
Dietary Phytoestrogens, Heather B. Patisaul and Patricia L. Whitten
Estrogens, Xenoestrogens and the Development of Neoplasms, Ana M. Soto and Carlos Sonnenschein
Molecular Mechanisms of Endocrine Disruption in Estrogen Dependent Processes, Robert M. Bigsby, Minerva Mercado-Feliciano, and Josephine Mubiru
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Environmental Antiestrogens: Characterization and Mechanism of Action, Stephen H. Safe
Section II Effect on the Male Reproductive System
Endocrine Disruptors and Male Infertility, Suresh C. Sikka, Muammer Kendirci, and Rajesh Naz
Environmental Androgens and Antiandrogens: An Expanding Chemical Universe, L. Earl Gray, Jr., Vickie Wilson, Tammy Stoker, Christy Lambright, Johnathan Furr, Nigel Noriega, Phillip Hartig, Mary Cardon, Mitch Rosen, Gerald Ankley, Andrew Hotchkiss, Edward F. Orlando, Louis J. Guillette, and William R. Kelce
Endocrine Disruptors and Male Sexual Dysfunction, Suresh C. Sikka, Muammer Kendirci, and Rajesh Naz
Prostate Development: Mechanisms for Opposite Effects of Low and High Doses of Estrogenic Chemicals, Catherine A. Richter, Barry G. Timms, and Frederick S. vom Saal
Metal Ions as Endocrine Disruptors: Implications for Prostate Cancer, Shuk-Mei Ho

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