Endothelium, Nitric Oxide and Atherosclerosis: From Basic Mechanisms to Clinical Implications / Edition 1

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Overview

The opening chapter of this book, by scientist Dr. Robert Furchgott, details the discovery of endothelium’s role in the vasodilator effect of acetycholine in 1978. Its subsequent identification as nitric oxide has been critical to cardiovascular medicine in understanding the regulation of vascular homeostasis. This simple observation won Dr. Furchgott a Nobel Prize in 1998.

Spanning from these initial observations to recent clinical investigations, this work offers an invaluable historical reference and clinical explanation about the intracellular mechanisms that regulate and stimulate endothelial nitric oxide synthase (eNOS). The basic mechanisms leading to endothelial dysfunction in cardiovascular disease complement information about the biological role and regulation of endothelial nitric oxide. Clinical studies of impaired endothelial function in patients with different cardiovascular conditions also reveal important and effective therapeutic strategies.

Written for both established physicians and scientists investigating the basic mechanisms and treatment of cardiovascular disease, as well as medical students who want to initiate themselves in the study of endothelial regulation of vascular physiology, many will find this comprehensive review a stimulus for new research.

The book contains predominantly color illustrations, with some black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: John F. Moran, MD (Loyola University Stritch School of Medicine)
Description: This is a review of the importance of nitric oxide to endothelial homeostasis in health and disease. The multi-authored text is divided into four parts covering the endothelium and nitric oxide, basic mechanisms of endothelial dysfunction, clinical studies of endothelial dysfunction, and therapeutic strategies to improve endothelial dysfunction. The book commemorates the Nobel Prize work by Dr. Robert Furchgott and the 50th Anniversary of the National Heart Lung and Blood Institute.
Purpose: The purpose is to provide discussions of the biology and regulation of nitric oxide and the basic mechanisms of endothelial dysfunction and cardiovascular disease, most notably, atherosclerosis. These are, indeed, worthy objectives and point to the central role of nitric oxide in the endothelium.
Audience: This is a comprehensive review of endothelial regulation of vascular physiology and is intended for medical students, trainees, physicians, and scientists who are interested in this area of nitric oxide and atherosclerotic cardiovascular disease.
Features: The focus is on the biology of nitric oxide and its effect on the endothelium both in the normal state and in cases of cerebral ischemia, hypertension, and problems of cardiac contractility (i.e., systolic and diastolic dysfunction). There is a good section on atherosclerosis which is an endothelial response to injury. The importance of hypercholesterolemia, hypertension, and diabetes in diminishing the bioactivity of nitric oxide on the endothelium is well documented. There are good pieces on estrogens and how they modulate production of nitric oxide. The section on basic mechanisms of endothelial dysfunctions and the clinical studies done in this area is particularly well done. The role of endothelin and nitric oxide in hypertension and the section on hypercholesterolemia are particularly good. The references to major works in these areas are well documented and up-to-date.
Assessment: Nitric oxide plays a critical role in the homeostasis of the arterial wall and the regulation of its vascular tone in inflammation and hemostasis. This is an important and readable text which is a definite addition to the medical literature.
John F. Moran
This is a review of the importance of nitric oxide to endothelial homeostasis in health and disease. The multi-authored text is divided into four parts covering the endothelium and nitric oxide, basic mechanisms of endothelial dysfunction, clinical studies of endothelial dysfunction, and therapeutic strategies to improve endothelial dysfunction. The book commemorates the Nobel Prize work by Dr. Robert Furchgott and the 50th Anniversary of the National Heart Lung and Blood Institute. The purpose is to provide discussions of the biology and regulation of nitric oxide and the basic mechanisms of endothelial dysfunction and cardiovascular disease, most notably, atherosclerosis. These are, indeed, worthy objectives and point to the central role of nitric oxide in the endothelium. This is a comprehensive review of endothelial regulation of vascular physiology and is intended for medical students, trainees, physicians, and scientists who are interested in this area of nitric oxide and atherosclerotic cardiovascular disease. The focus is on the biology of nitric oxide and its effect on the endothelium both in the normal state and in cases of cerebral ischemia, hypertension, and problems of cardiac contractility (i.e., systolic and diastolic dysfunction). There is a good section on atherosclerosis which is an endothelial response to injury. The importance of hypercholesterolemia, hypertension, and diabetes in diminishing the bioactivity of nitric oxide on the endothelium is well documented. There are good pieces on estrogens and how they modulate production of nitric oxide. The section on basic mechanisms of endothelial dysfunctions and the clinical studies done in this area isparticularly well done. The role of endothelin and nitric oxide in hypertension and the section on hypercholesterolemia are particularly good. The references to major works in these areas are well documented and up-to-date. Nitric oxide plays a critical role in the homeostasis of the arterial wall and the regulation of its vascular tone in inflammation and hemostasis. This is an important and readable text which is a definite addition to the medical literature.
Booknews
Offers a complete review of advances in the treatment of endothelial dysfunction, covering historical aspects, the latest techniques, and clinical explanation about the intracellular mechanisms that regulate and stimulate endothelial nitric oxide synthase. Contains sections on endothelium and biology of nitric oxide, basic mechanisms of endothelial dysfunction, clinical studies of endothelial function and dysfunction, and therapeutic strategies to improve endothelial dysfunction. For physicians and scientists investigating basic mechanisms and treatment of cardiovascular disease, as well as medical students. The editors are associated with the National Institutes of Health, Bethesda, Maryland. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780879934361
  • Publisher: Wiley
  • Publication date: 7/28/1999
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 320
  • Product dimensions: 7.20 (w) x 10.23 (h) x 1.00 (d)

Table of Contents

Preface.

Julio A. Panza and Richard O. Cannon.

Contributors.

Part I: The Endothelium and the Biology of Nitric Oxide.

Chapter 1: Discovery of Endothelium-Derived Relaxing Factor and Its Identification as Nitric Oxide.

Robert F. Furchgott.

Chapter 2: Discovery of Biological Roles of Nitric Oxide in the Cardiovascular System.

Salvador Moncada and E. Annie Higgs.

Chapter 3: Molecular Mechanisms of Intracellular Endothelium Nitric Oxide Regulation.

William E. Downey and Thomas Michel.

Chapter 4: Cardiovascular Effects of Nitric Oxide: Lessons Learned from Endothelial Nitric Oxide Synthase Knockout Mice.

Paul L. Huang, Robert Gyurko, and Lin Zhang.

Chapter 5: Nitric Oxide Signaling Mediating Relaxation of Vascular Smooth Muscle.

Richard A. Cohen.

Chapter 6: Hemoglobin-Bound Nitric Oxide Participates in the Mammalian Respiratory Cycle.

Timothy J. McMahon and Jonathan S. Stamler.

Chapter 7: Hormonal Regulation of Endothelium-Derived Factors.

Virginia M. Miller.

.

Part II: Basic Mechanisms of Endothelial Dysfunction.

Chapter 8: Endothelial Dysfunction and Vascular Disease.

Paul M. Vanhoutte.

Chapter 9: Endothelium-Derived Constricting Factors and Endothelial Dysfunction.

Frank T. Ruschitzka, Georg Noll, and Thomas F. Lüscher.

Chapter 10: Endothelial Nitric Oxide and Vascular Inflammation.

James K. Liao.

Chapter 11: Vascular Oxidant Stress and Nitric Oxide Bioactivity.

A. Maziar Zafari, David G. Harrison, and Kathy K. Griendling.

.

Part III: Clinical Studies of Endothelial Function and Dysfunction.

Chapter 12: Endothelium, Nitric Oxide, and Hypertension.

Julio A. Panza.

Chapter 13: Nitric Oxide Availability in Hypercholesterolemia.

Robert A. Vogel.

Chapter 14: Nitric Oxide Activity in the Human Coronary Circulation.

Arshed A. Quyyumi.

Chapter 15: Endothelial Vasodilator Dysfunction in Chronic Heart Failure.

Helmut Drexler and Burkhard Hornig.

Chapter 16: In Vitro Studies of the Human Microcirculation in Cardiovascular Disorders.

Anthony M. Heagerty.

.

Part IV: Therapeutic Strategies to Improve Endothelial Dysfunction.

Chapter 17: Endothelium as a Target of the Risk Factors in Cardiovascular Disease.

Scott Kinlay, Andrew P. Selwyn, and Peter Ganz.

Chapter 18: Oxidant Stress and Endothelial Function in Patients with Risk Factors for Atherosclerosis.

Mark A. Creager.

Chapter 19: Endothelium-Derived Nitric Oxide: An Antiatherogenic Molecule.

Shanthi Adimoolam and John P. Cooke.

Chapter 20: Hormone Therapy and Nitric Oxide Bioactivity in Postmenopausal Women.

Richard O. Cannon III.

Chapter 21: Clinical Trials Using Angiotensin-Converting Enzyme Inhibition to Alter Endothelial Dysfunction in Coronary Patients.

G. B. John Mancini.

Chapter 22: Nitrate Therapy in Cardiovascular Disease.

Jonathan Abrams.

Index

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