Endotoxins: Structure, Function and Recognition / Edition 1

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Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

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Editorial Reviews

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“The book consists of two parts that include 17 chapters prepared by an international team of well_ known experts. … The book is well prepared. There are many good quality photos, graphs, and pictures. Each chapter ends with a base reference, and there is a subject index at the end of the book. … very useful for many researchers in the field of biochemistry, biotechnology, immunology, and medicinal chemistry. This book can also be a useful tool for teachers and students of colleges and universities.” (G. Ya. Wiederschain, Biochemistry, Vol. 76 (5), May, 2011)

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Product Details

  • ISBN-13: 9789048190775
  • Publisher: Springer Netherlands
  • Publication date: 7/12/2010
  • Series: Subcellular Biochemistry Series, #53
  • Edition description: 2010
  • Edition number: 1
  • Pages: 415
  • Product dimensions: 6.30 (w) x 9.20 (h) x 1.30 (d)

Table of Contents

Part I Structure and Properties of Endotoxins

1 Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria Xiaoyuan Wang Peter J. Quinn 3

2 Purification and Characterization of Lipopolysaccharides Xiaoyuan Wang Chan Zhang Feng Shi Xiaoqing Hu 27

3 Endotoxins: Relationship Between Structure, Function, and Activity K. Brandenburg A.B. Schromm T. Gutsmann 53

4 The Diversity of the Core Oligosaccharide in Lipopolysaccharides Alba Silipo Antonio Molinaro 69

5 Salmonella-Regulated Lipopolysaccharide Modifications Susan M. Richards Kristi L. Strandberg John S. Gunn 101

6 The Variation of O Antigens in Gram-Negative Bacteria Lei Wang Quan Wang Peter R. Reeves 123

7 Regulators of TLR4 Signaling by Endotoxins Anne F. McGettrick Luke A.J. O'Neill 153

8 Membrane Partitioning: Is Location Everything When It Comes to Endotoxin Recognition? Martha Triantafilou Kathy Triantafilou 173

Part II Infection, Treatment and Immunity

9 Endotoxin Detection-from Limulus Amebocyte Lysate to Recombinant Factor C Jeak Ling Ding Bow Ho 187

10 The Role of Endotoxin in Infection: Helicobacter pylori and Campylobacter jejuni Anthony P. Moran 209

11 The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection Samuel M. Moskowitz Robert K. Ernst 241

12 Development of Small-Molecule Endotoxin Sequestering Agents Sunil A. David Diptesh Sil 255

13 Development of an Anti-Endotoxin Vaccine for Sepsis Alan S. Cross 285

14 Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants Christopher B. Fox Martin Friede Steven G. Reed Gregory C. Ireton 303

15 Targeting Endotoxin in the Treatment of Sepsis Jean-Sebastien Rachoin Christa A. Schorr R. Phillip Dellinger 323

16 Lipopolysaccharides in Rhizobium-Legume Symbioses Russell W. Carlson L. Scott Forsberg Elmar L. Kannenberg 339

17 Lipopolysaccharides and Plant Innate Immunity G. Erbs A. Molinaro J.M. Dow M.-A. Newman 387

Index 405

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