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Doody's Review ServiceReviewer: Gene A. Homandberg, PhD (Rush Medical College of Rush University)
Description: This monograph in the Methods in Enzymology series presents contributions from 60 experts on thermodynamic methods for determining functional energetics of ligand interaction with macromolecules, conformational changes in protein and nucleic acids, macromolecular assembly, allosteric regulation, phase transitions, protein nucleic acid recognition, and the role and coupling of these processes in enzyme catalysis and other activities of macromolecules.
Purpose: The purpose is to review applications of various classical and newer methods used to study the energetics of biological macromolecules in many diverse systems. Additional overview or summary chapters that educate the reader on the importance of such studies or how such approaches can be linked together to describe a particular biologic system would have been helpful for less informed readers. Nonetheless, the chapters on studies of nucleic acid conformation and energetics of interaction with chemically modified DNA binding proteins will be particularly appealing to many molecular biologists and do illustrate the usefulness and currency of the described methods.
Audience: The book is intended for biochemists and molecular biologists in general. These topics should be particularly useful to many different types of researchers, including protein chemists, molecular biologists, enzymologists, and pharmaceutical biochemists.
Features: The monograph features informative black-and-white illustrations, all presented in an attractive format typical of this series and suitable in number, quality, and information content.
Assessment: This book should be very useful to researchers as well as students who study either protein or nucleic acids. Because some of the basic classical topics that have been covered before in other series are now brought more up to date and because the book illustrates current relevance by including studies of protein-nucleic acid interaction, this volume is more appealing to both students and experienced researchers studying biologic systems.