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Energetics of Biological Macromolecules, Part B
     

Energetics of Biological Macromolecules, Part B

by Elsevier Science
 

General Description of the Volume:
The very existence of biological structures and their functional interactions are dictated by energetic relationships. Thus the central theme of this volume is that thermodynamic methods, i.e. techniques that probe the energetics of biological macromolecules, now comprise a powerful and practical family of tools for

Overview

General Description of the Volume:
The very existence of biological structures and their functional interactions are dictated by energetic relationships. Thus the central theme of this volume is that thermodynamic methods, i.e. techniques that probe the energetics of biological macromolecules, now comprise a powerful and practical family of tools for research in modern biology. The application of thermodynamics and statistical thermodynamics to biochemical and biophysical systems is presented. This volume supplements Methods in Enzymology, Volume 259.
General Description of the Series:
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences.

Key Features
• Major topics covered include:
• Deciphering rules of helix stability in peptides
• Protein Folding in Membranes
• Molecular Crowding
• Study of the Bohr Effect in Hemoglobin Intermediates
• Photoacoustic Calorimetry of Proteins
• Theoretical Aspects of Isothermal Titration Calorimetry
• Energetic Methods to Study Bifunctional Biotin Repressor

Editorial Reviews

Doody's Review Service
Reviewer: Gene A. Homandberg, PhD (Rush Medical College of Rush University)
Description: This volume honors K.E. van Holde for his many contributions to studies of energetics of protein folding, protein assembly and biologic recognition, and ligand-ligand interaction. It includes 24 chapters by experts who cover areas including determination of the energetics of protein-bilayer interactions; molecular design of peptide ligands; study of the Bohr effect in hemoglobin interactions; and photoacoustic calorimetry of proteins and studies of interactions and folding of repressor proteins.
Purpose: This volume is meant to cover topics to which van Holde made contributions and to include newer methologic approaches and applications that should be of general interest. While some of these chapters are very specific, they illustrate the potential of these applications to other study systems. Nonetheless, this volume was not meant to be a general volume that focuses on only the most commonly used methods.
Audience: The audience could include anyone from student to experienced structural biologist or protein chemist. Each chapter is well written, very concise, yet very informative, and should be interesting reading for investigators at different levels of training. This book should be informative to anyone with a need to understand how to characterize protein structure and activities and an interest in the specific methods and applications presented.
Features: The features include many informative illustrations with very useful, very extensive bibliographies. The book is in the form of the attractive Methods in Enzymology series.
Assessment: This would be a worthwhile addition to the library of anyone with interests in energetics of protein folding and protein ligand interaction. Since the editors and contributors are internationally recognized experts, the content is very meaningful.
From the Publisher
Praise for the Volume
"Each chapter is well written, very concise, yet very informative, and should be interesting reading for investigators at different levels of training... The features include many informative illustrations with very useful, very extensive bibliographies... This would be a worthwhile addition to the library of anyone with interests in energetics of protein folding and protein ligand interaction. Since the editors and contributors are internationally recognized experts, the content is very meaningful."
—DOODY'S Publishing Reviews
Praise for the Series
"The Methods in Enzymology series represents the gold-standard."
—NEUROSCIENCE
"Incomparably useful."
—ANALYTICAL BIOCHEMISTRY
"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page."
—BIO/TECHNOLOGY
"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection."
—CHEMISTRY IN INDUSTRY
"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced."
—AMERICAN SOCIETY OF MICROBIOLOGY NEWS
"If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work."
—ENZYMOLOGIA
"A series that has established itself as a definitive reference for biochemists."
—JOURNAL OF CHROMATOGRAPHY
4 Stars! from Doody
Gene A. Homandberg
This volume honors K.E. van Holde for his many contributions to studies of energetics of protein folding, protein assembly and biologic recognition, and ligand-ligand interaction. It includes 24 chapters by experts who cover areas including determination of the energetics of protein-bilayer interactions; molecular design of peptide ligands; study of the Bohr effect in hemoglobin interactions; and photoacoustic calorimetry of proteins and studies of interactions and folding of repressor proteins. This volume is meant to cover topics to which van Holde made contributions and to include newer methologic approaches and applications that should be of general interest. While some of these chapters are very specific, they illustrate the potential of these applications to other study systems. Nonetheless, this volume was not meant to be a general volume that focuses on only the most commonly used methods. The audience could include anyone from student to experienced structural biologist or protein chemist. Each chapter is well written, very concise, yet very informative, and should be interesting reading for investigators at different levels of training. This book should be informative to anyone with a need to understand how to characterize protein structure and activities and an interest in the specific methods and applications presented. The features include many informative illustrations with very useful, very extensive bibliographies. The book is in the form of the attractive Methods in Enzymology series. This would be a worthwhile addition to the library of anyone with interests in energetics of protein folding and protein ligand interaction. Since the editorsand contributors are internationally recognized experts, the content is very meaningful.
Booknews
The second ensemble in the series of biothermodynamic articles, especially useful for researchers and students whose goal is to connect the functional energetics of macromolecular structures with their biological functions. Twenty-four articles include tight ligand binding affinities determined from thermodynamic linkage to temperature by titration calorimetry; application of automated methods for determination of protein conformational stability; kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors; and energetic methods to study the bifunctional biotin operon repressor. Annotation c. by Book News, Inc., Portland, Or.

Product Details

ISBN-13:
9780121821968
Publisher:
Elsevier Science
Publication date:
08/26/1998
Series:
Methods in Enzymology Series
Edition description:
New Edition
Pages:
548

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